Aim: To examine the relation of doxapram to a developmental score achieved by a structured telephone interview in a group of extremely-preterm-born children.
Methods: Parents of 88 children born extremely preterm were contacted by telephone and interviewed by a structured questionnaire (R-PDQ) when the corrected age of their child was 9-15 mo.
Results: We found that doxapram treatment was associated with a deficit in age-adjusted R-PDQ score.
Conclusion: Doxapram may have a negative effect on neurodevelopmental outcome.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/08035250500254449 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Doxapram for apnoea of prematurity and neurodevelopmental outcomes at age 5-6 years.
Arch Dis Child Fetal Neonatal Ed
June 2024
Sorbonne Paris-Nord, Inserm, INRAE, CRESS, Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, Université Paris Cité, Paris, France.
Objective: To assess the long-term neurodevelopmental impact of doxapram for treating apnoea of prematurity.
Design: Secondary analysis of the French national cohort study EPIPAGE-2. Recruitment took place in 2011.
The bioavailability and maturing clearance of doxapram in preterm infants.
Pediatr Res
April 2021
Leiden Amsterdam Center for Drug Research (LACDR), Division of Pharmacology, LACDR, Leiden University, Leiden, The Netherlands.
Background: Doxapram is used for the treatment of apnea of prematurity in dosing regimens only based on bodyweight, as pharmacokinetic data are limited. This study describes the pharmacokinetics of doxapram and keto-doxapram in preterm infants.
Methods: Data (302 samples) from 75 neonates were included with a median (range) gestational age (GA) 25.
Caffeine for the Treatment of Apnea in the Neonatal Intensive Care Unit: A Systematic Overview of Meta-Analyses.
Paediatr Drugs
August 2020
College of Pharmacy, QU Health, Qatar University, Doha, Doha, Qatar.
Background: Caffeine is a common treatment for neonatal intensive care management of the developmental complication of apnea of prematurity in preterm infants. There are several systematic reviews (SRs) on the performance of caffeine in the treatment of apnea. The evidence provided by those, however, is depressed by an information overload due to high heterogeneity in the characteristics as well as the quality of these SRs.
View Article and Find Full Text PDFLong-Term Neurodevelopmental Outcome after Doxapram for Apnea of Prematurity.
Neonatology
November 2017
Department of Neonatology, Emma Children's Hospital, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
Background: Doxapram has been advocated as a treatment for persistent apnea of prematurity (AOP).
Objective: To evaluate the effect of doxapram on long-term neurodevelopmental outcome in preterm infants as its safety still needs to be established.
Methods: From a retrospective cohort of preterm infants with a gestational age (GA) <30 weeks and/or a birth weight <1,250 g, born between 2000 and 2010, infants treated with doxapram (n = 142) and a nontreated control group were selected (n = 284).
Low cost of pulmonary ventilation in American alligators (Alligator mississippiensis) stimulated with doxapram.
J Exp Biol
April 2016
Zoophysiology, Department of Bioscience, Aarhus University, 8000 Aarhus C, Denmark.
To determine the costs of pulmonary ventilation without imposing severe oxygen limitations or acidosis that normally accompany exposures to hypoxia or hypercapnia, we opted to pharmacologically stimulate ventilation with doxapram (5 and 10 mg kg(-1)) in alligators. Doxapram is used clinically to alleviate ventilatory depression in response to anaesthesia and acts primarily on the peripheral oxygen-sensitive chemoreceptors. Using this approach, we investigated the hypothesis that pulmonary ventilation is relatively modest in comparison to resting metabolic rate in crocodilians and equipped seven juvenile alligators with masks for concurrent determination of ventilation and oxygen uptake.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!