AI Article Synopsis
- Electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS) are brain stimulation methods used to treat major depression, but their exact therapeutic mechanisms are still not fully understood.
- A case report involving two patients revealed that after successful treatment with ECT and rTMS, both experienced a decrease in motor cortical excitability measured through motor-evoked potentials, indicating the techniques affect brain activity related to motor function.
- The study suggests that tracking motor cortical excitability may be valuable for understanding and monitoring the effects of various antidepressant brain stimulation therapies.
Article Abstract
Electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex are brain stimulation techniques that are used as therapeutic interventions in major depression. However, the exact therapeutic mode of action needs further clarification. In this case report, we describe the impact of these stimulation techniques on motor cortical excitability, as revealed by transcranial magnetic stimulation-elicited motor-evoked potentials in 2 patients who received consecutively both rTMS and ECT. Both patients showed a decrease in motor cortical excitability after response to antidepressant brain stimulation, whereas parameters of motor cortical excitability remained unchanged after the first non-successful intervention. These results suggest that both ECT and rTMS may have an impact on parameters of motor cortical neuronal excitability. Furthermore, measurement of motor cortical excitability may be a useful tool for investigating and monitoring inhibitory brain effects of different antidepressant stimulation techniques.
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| http://dx.doi.org/10.1097/01.yct.0000180039.12176.9c | DOI Listing |
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