AI Article Synopsis
- There is inconsistent evidence regarding how sex hormone levels affect cognitive function and brain volume in older men, particularly from studies using MRI.
- The study aimed to see if testosterone, estradiol, estrone, and SHBG levels in midlife could predict cognitive performance and brain volume nearly a decade later in WWII veteran twins.
- Findings indicated no significant links between sex hormones and cognitive tasks, but higher testosterone levels correlated with larger brain volumes in some regions, suggesting that sex hormones might influence brain structure before any impact on cognitive abilities becomes noticeable.
Article Abstract
Background: There is inconsistent evidence of the presence and direction of the relationship between sex hormone concentrations and cognitive function in older men, and there is little published literature on the relationship of sex hormone concentrations and brain volume as measured by MRI.
Objective: To examine the hypothesis that midlife total serum concentrations of testosterone (T), estradiol, estrone, and sex hormone binding globulin (SHBG) predict cognitive task performance and regional brain volumes at 10- to 16-year follow-up, in a longitudinal sample of World War II veteran twin men.
Methods: Treating twins as individuals, linear regression models were used, adjusting analyses for age, education, depressive symptomatology, blood pressure, alcohol consumption, years of cigarette smoking, and APOE epsilon4 allele status.
Results: There were no significant associations between sex hormone or SHBG concentrations and performance on a series of cognitive tasks measuring global and executive function, visual and verbal learning and memory. Higher midlife T concentrations were associated with larger hemispheric, frontal, and parietal regional brain volumes and with smaller left occipital brain volume. Higher estradiol and estrone concentrations were also associated with smaller right (estradiol) and both right and left (estrone) occipital volumes, but with no other brain regions. Owing to the multiple comparisons conducted, some significant associations may have occurred by chance.
Conclusions: Overall, the pattern of results suggests a role for sex hormones in brain volume that predates potentially observable associations between sex hormones and cognitive task performance.
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| http://dx.doi.org/10.1212/01.wnl.0000184512.08249.48 | DOI Listing |
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