AI Article Synopsis
- Research identifies CRTAM, a novel member of the immunoglobulin supergene family, which is particularly abundant in the human cerebellum's Purkinje neurons.
- CRTAM is part of the nectin-like family, and its interaction with Necl-2 could facilitate neuronal connections in the cerebellum.
- In the immune system, CRTAM is predominantly found on activated class-I MHC-restricted T cells, indicating its potential use as a diagnostic marker for viral and autoimmune diseases.
Article Abstract
We have previously reported the characterization of a novel immunoglobulin supergene family member, designated class-I MHC-restricted T cell associated molecule (CRTAM). Here we further characterize human CRTAM and find that it is highly expressed in the cerebellum, notably in Purkinje neurons. We identify CRTAM as a new member of the nectin-like (Necls) family and find significant expression of Necl-2 (IGSF4), a protein known to bind CRTAM and another member of the nectin superfamily, in the cerebellum. These findings suggest that CRTAM/Necl-2 binding may contribute to neuronal interactions. We also show that, in the immune system, CRTAM expression is restricted to activated class-I MHC-restricted T cells, including NKT and CD8 T cells. CRTAM represents one of the most highly expressed surface markers of activated human CD8 T cells and NKT cells, suggesting it may have diagnostic uses in various human viral and autoimmune diseases.
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| http://dx.doi.org/10.1016/j.jneuroim.2005.09.017 | DOI Listing |
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