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Application value of CT three-dimensional reconstruction technology in the identification of benign and malignant lung nodules and the characteristics of nodule distribution.
BMC Med Imaging
January 2025
Department of Radiology, The First Affiliated Hospital of Yangtze University, No. 40 Jinlong Road, Shashi District, Jingzhou, Hubei, 434000, China.
Objective: The study aimed to evaluate the application value of computed tomography (CT) three-dimensional (3D) reconstruction technology in identifying benign and malignant lung nodules and characterizing the distribution of the nodules.
Methods: CT 3D reconstruction was performed for lung nodules. Pathological results were used as the gold standard to compare the detection rates of various lung nodule signs between conventional chest CT scanning and CT 3D reconstruction techniques.
Integrating Ultrabright Polymer Dots and Stereo NIR-II Imager for Assessing Anti-Angiogenic Drugs in Oral Cancer Model.
J Cell Mol Med
January 2025
Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
The development of efficient platforms for the evaluation of anti-angiogenic agents is critical in advancing cancer therapeutics. In this study, we exploited an ultrabright semiconducting polymer dots (Pdots) integrating with a three-dimensional (3D) near-infrared-II (NIR-II) fluorescence imaging system designed to assess the efficacy of potent anti-angiogenic agents PX-478 and BPR0C261 in an oral squamous cell carcinoma (OSCC) tumour model, which depends on angiogenesis for dissemination. PX-478, a hypoxia-inducible factor-1α (HIF-1α) inhibitor, and BPR0C261, a microtubule-disrupting agent, were administrated into tumour-bearing mice established using murine MTCQ1 tongue cancer cells through intraperitoneal injection and oral gavage, respectively.
View Article and Find Full Text PDFReal-Time Volumetric Free-Hand Ultrasound Imaging for Large-Sized Organs: A Study of Imaging the Whole Spine.
Ultrasound Med Biol
January 2025
Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.
Objectives: Three-dimensional (3D) ultrasound imaging can overcome the limitations of conventional two-dimensional (2D) ultrasound imaging in structural observation and measurement. However, conducting volumetric ultrasound imaging for large-sized organs still faces difficulties including long acquisition time, inevitable patient movement, and 3D feature recognition. In this study, we proposed a real-time volumetric free-hand ultrasound imaging system optimized for the above issues and applied it to the clinical diagnosis of scoliosis.
View Article and Find Full Text PDFChiral helical scaffolds: Unlocking their potential in biomolecular interactions and biomedical applications.
Biotechnol Adv
January 2025
Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 775 15 Olomouc, Czech Republic. Electronic address:
In nature, various molecules possess spiral geometry. Such helical structures are even prevalent within the human body, represented classically by DNA and three-dimensional (secondary structure) protein folding. In this review, we chose helicenes and helicene-like structures -synthetically accessible carbon-rich molecules- as a compelling example of helically chiral scaffolds.
View Article and Find Full Text PDFCorrelation between different boundaries used in upper airway assessment.
BMC Oral Health
January 2025
Department of Orthodontics, Case Western Reserve University School of Dental Medicine, Cleveland, OH, 44106, USA.
Background: The aim of this study was to evaluate the correlation of the volume and minimum axial area (MAA) measurements between different upper and lower boundaries used for oropharyngeal airway assessment.
Methods: Cone Beam Computed Tomography (CBCT) scans of 49 subjects taken for pre-orthognathic surgical planning were obtained retrospectively from the archives (n = 49; 32 females, 17 males; mean age = 20.9 ± 5.
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