Phagocytosis and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2-/-) polymorphonuclear leukocytes (PMN). Phagocytosis of green fluorescent protein-transformed pneumococci was delayed in TLR2-/- PMN. These cells exhibited also a lower oxidative bactericidal activity against S. pneumoniae than WT PMN, suggesting that TLR2 modulates bacterial clearance in PMN.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1307087 | PMC |
| http://dx.doi.org/10.1128/IAI.73.12.8397-8401.2005 | DOI Listing |
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