AI Article Synopsis
- Ghrelin, a hormone that stimulates appetite, is produced in various tissues, including salivary and stomach glands, and acts on specific neurons in the brain.
- One of the significant symptoms of stomach cancer is loss of appetite, prompting a study to investigate ghrelin production in salivary glands and stomach cancer tissues.
- Immunohistochemistry results showed that cancer tissues do not produce ghrelin, while normal tissues do, suggesting a link between reduced food intake in cancer patients and the lack of ghrelin production in tumors.
Article Abstract
Ghrelin (G-HH) synthesized in several tissues including salivary and stomach glands stimulates appetite in humans by modulating neuropeptide Y neurons in the hypothalamic arcuate nucleus. Loss of appetite is one of the most important symptoms of stomach cancer. We conducted a study using immunohistochemistry to determine whether salivary glands and stomach cancer tissues produce ghrelin. We determined that negative ghrelin immunohistochemistry discriminates tumors from normal tissues and may therefore further our understanding of the clinically important problem of reduced food intake and anorexia in cancer patients. Radioimmunoassay analyses confirmed that cancer cells do not produce a G-HH peptide, whereas normal cells yield this peptide.
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| http://dx.doi.org/10.1080/10520290500387847 | DOI Listing |
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