Shift work is related to problems in sleep/wakefulness and social life. The effects of a very rapidly forward rotating shift system on sleep, health and well-being of young (-45) and elderly (45+) maintenance workers were studied by a controlled intervention study. In the beginning, all the workers had a continuous backward rotating three-shift system. A very quickly forward rotating shift system was developed, avoiding consecutive night shifts and with more free-time between the individual shifts. The effect of the new shift system on sleep/wakefulness and general well-being was studied by questionnaire and field studies including on-site registration of sleep (actigraphy), subjective sleepiness (KSS) and psychomotor performance (PVT). Based on a linear mixed model for repeated measurements, the new shift system increased the main sleep length after the night shift and improved alertness and PVT performance during the night shift among the older workers. Alertness also improved during free-time after the night shift and sleep complaints decreased after all shifts. The workers on the new shift schedule perceived the effects of the new shift system on sleep, alertness, general health, well-being at work, social and family life more positively than the workers in the old shift system. At the end of the study, all subjects voted for the new shift system. It is concluded that although the new shift system increased the operating hours at night, the very rapidly forward rotating shift system had positive effects on the sleep, alertness and well-being of especially the older shift workers.
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http://dx.doi.org/10.1016/j.ijpsycho.2005.08.005 | DOI Listing |
Science
January 2025
Department of Geoinformatics, University of Kashmir, Srinagar, India.
On 3 October 2023, a multihazard cascade in the Sikkim Himalaya, India, was triggered by 14.7 million m of frozen lateral moraine collapsing into South Lhonak Lake, generating an ~20 m tsunami-like impact wave, breaching the moraine, and draining ~50 million m of water. The ensuing Glacial Lake Outburst Flood (GLOF) eroded ~270 million m of sediment, which overwhelmed infrastructure, including hydropower installations along the Teesta River.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Medicine and Health Technology, Department of Ophthalmology, Tampere University, Tampere, Finland.
Background: The long-term patterns in first-line glaucoma medication are not well established. Exploring these in longitudinal and population-based settings would provide information for the healthcare systems to plan glaucoma care accordingly.
Objective: To evaluate patterns in first-line glaucoma monotherapy in Finland during 1995-2019 based on nationwide survey and register data.
ACS Nano
January 2025
Nanomedicine Center, The Great Bay Area National Institute for Nanotechnology Innovation, 136 Kaiyuan Avenue, Guangzhou 510700, China.
The neurological implications of micro- and nanoplastic exposure have recently come under scrutiny due to the environmental prevalence of these synthetic materials. Parkinson's disease (PD) is a major neurological disorder clinically characterized by intracellular Lewy-body inclusions and dopaminergic neuronal death. These pathological hallmarks of PD, according to Braak's hypothesis, are mediated by the afferent propagation of α synuclein (αS) via the enteric nervous system, or the so-called gut-brain axis.
View Article and Find Full Text PDFLab Chip
January 2025
CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230027, P. R. China.
We propose a novel contactless droplet manipulation strategy that combines electrostatic tweezers (ESTs) with lubricated slippery surfaces. Electrostatic induction causes the droplet to experience an electrostatic force, allowing it to move with the horizontal shift of the EST. Because both the EST and the slippery operating platform prepared by a femtosecond laser exhibit a strong binding effect on droplets, the EST droplet manipulation features significant flexibility, high precision, and can work under various operating conditions.
View Article and Find Full Text PDFCurr Opin Organ Transplant
January 2025
Division of Nephrology, Virginia Commonwealth University, Richmond, Virginia, USA.
Purpose Of The Review: Calcineurin inhibitors (CNIs) are central to immunosuppression in kidney transplantation (KT), improving short-term outcomes but falling short in enhancing long-term outcomes due to cardiovascular, metabolic, and renal complications. Belatacept, an FDA-approved costimulation blocker, offers a less toxic alternative to CNIs but is limited by its intravenous administration and reduced efficacy in high-immunological-risk patients.
Recent Findings: Emerging therapies target more specific pathways to improve efficacy and accessibility.
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