Reasons For Performing Study: Injuries of the equine stifle are frequent causes of hindlimb lameness. Ultrasonography is useful for the diagnosis of many soft tissue lesions but, until recently, its application to the equine stifle has been limited to a description of normal and abnormal structures. A comparative study using gross anatomical sections to identify all structures visible on ultrasonographic images of the equine stifle has not previously been reported.
Objectives: To provide a comprehensive comparative cross-sectional atlas of the normal equine medial femorotibial (MFT) joint and its related structures using ultrasonography.
Methods: The stifle joints of 15 cadaver limbs were examined ultrasonographically using a systematic approach. Ten different scanning planes were defined. The lateral and medial femorotibial and the femoropatellar joints were injected with pigments of different colours. Each leg was frozen (10 in extension and 5 in flexion) and cut into slices corresponding to the different scanning planes. According to the different ultrasonographic reference images, 10 representative anatomical images were selected and digitised.
Results: All bony and soft tissue structures were identified on the anatomical sections and subsequently located on the corresponding ultrasonographic images, except the caudal meniscotibial ligaments. Visualisation of the cruciate ligaments was a challenge due to their position and oblique orientation.
Conclusions: Ultrasonography is a very useful technique for imaging both soft tissue and bony structures of the MFT joint and its related structures, although a protocol is required to perform a systematic and standardised ultrasonographic examination. Good anatomical knowledge is mandatory for identification of the different structures.
Potential Relevance: This study should contribute to 1) knowledge of the ultrasonographic anatomy of the equine MFT joint and its related structures, 2) use of a protocol for a standardised ultrasonographic examination and 3) the ability to recognise abnormal structures.
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http://dx.doi.org/10.2746/042516405775314817 | DOI Listing |
Clin Oral Investig
January 2025
Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
Objectives: This study was aimed to investigate the efficacy of comprehensive conservative treatments in patients with temporomandibular joint (TMJ) retrodiscal layer rupture and/or disc perforation.
Materials And Methods: This was a retrospective study of thirty-one consecutive patients with findings of TMJ retrodiscal layer rupture and/or disc perforation using magnetic resonance imaging. Comprehensive stomatognathic system assessments were performed.
Adv Biotechnol (Singap)
September 2024
MOE Key Laboratory of Gene Function and Regulation, Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, 510275, China.
Although significant progress of clinical strategy has been made in gene editing and cell engineering in immunotherapy, it is now apparent that design and modification in terms of complex signaling pathways and motifs on medical synthetic biology are still full of challenges. Innate immunity, the first line of host defense against pathogens, is critical for anti-pathogens immune response as well as regulating durable and protective T cell-mediated anti-tumor responses. Here, we introduce DSCI (Database of Synthetic Biology Components for Innate Immunity, https://dsci.
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January 2025
Center for Infectious Diseases, Lab of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Unlabelled: Due to increasing antimicrobial resistance and side effects caused by current standard antimicrobial regimens used for treatment of prosthetic joint infection (PJI), alternative options are urgently needed. We aimed to investigate the effect of clindamycin in different exposure strategies against in an mature biofilm model. In short, 7-day biofilms were generated on polystyrene plates and titanium-aluminum-vanadium discs using a clinical PJI isolate.
View Article and Find Full Text PDFRSC Adv
January 2025
National and Local Joint Engineering Research Center of Advanced Packaging Material Research and Development Technology, School of Packaging and Materials Engineering, Hunan University of Technology Zhuzhou 412007 Hunan China
To further improve the performance of PA66 and expand its applications, a new strategy was proposed to introduce an alicyclic structure into PA66 chain by the copolymerization method. Initially, 3,3'-dimethyl-4,4'-diaminodicyclohexylmethane (MACM) was reacted with 1,6-adipic acid to form MACM6 salt, and then, it was copolymerized with PA66 salt to synthesize PA66/MACM6 copolymers with alicyclic structures. PA66/MACM6 copolymers exhibited good thermal stabilities, and the presence of alicyclic structure had no significant effect on their thermal stabilities.
View Article and Find Full Text PDFResearch (Wash D C)
January 2025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Na1.7 is considered a promising target for developing next-generation analgesic drugs, given its critical role in human pain pathologies. Although most reported inhibitors with strong in vitro activity and high selectivity share the aryl sulfonamide scaffold, they failed to demonstrate marked clinical efficacy.
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