One hundred male patients with acute gonococcal urethritis were treated with various antibiotic and chemotherapeutic regimens. Pivampicillin, 1400 mg orally in two divided does at 5 hours' interval gave 100% cure in 60 patients. Gentamicin, 280 mg IM in one dose was equally efficaceous in 15 patients. Ampicillin and Trimethoprim-sulfamethoxazole gave cure rates of around 70%. While the results of the first two groups were in agreement with data published in different parts of the world, our results with the later two groups were contrary to those of other authors. The need for periodic evaluation of various antibiotic regimens in the treatment of gonorrhea is indicated.

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