Objectives: Primary adenocarcinoma of the female urethra is a rare malignancy. We report two cases and a review of the latest articles focused on classification and treatment of this kind of neoplasm.

Methods: We present two females diagnosed of urethral adenocarcinoma, describing clinic and pathological features, diagnosis and treatment.

Conclusions: Female urethral adenocarcinoma is an uncommon neoplasm with a heterogeneous histogenesis. The distal urethral carcinoma is more amenable to treatment, and the prognosis is better than that of proximal or entire urethral carcinoma, which is often associated with extensive local invasion and metastasis.

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http://dx.doi.org/10.4321/s0004-06142005000700015DOI Listing

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