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Incidence of HTLV-1-associated myelopathy in the UK from 1991 to 2024: a longitudinal observational cohort study.
Front Med (Lausanne)
January 2025
Section of Virology, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom.
Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) may cause spinal cord inflammation, leading to HTLV-1-associated myelopathy (HAM). HAM is a chronic and progressive neurological disorder that is associated with increased mortality and impaired quality of life. There are limited data on the incidence of HAM, with higher rates seen in Latin America and the Caribbean compared to Japan.
View Article and Find Full Text PDFCase Report: Targeted plasticity in spinal cord injury-the role of focal muscle vibration and neurocognitive rehabilitation in adaptative synaptic change along sensory and motor circuit.
Front Rehabil Sci
January 2025
Department of Life Sciences, Health, and Health Professions, Link Campus University, Rome, Italy.
Purpose: The purpose of this case was to investigate objectively and quantitatively the effects of the application of repeated focal muscle vibration (fMV) associated with neurocognitive exercise on a 46-year-old patient with spastic paraparesis secondary to the surgical removal of a C5-C6 ependymoma.
Methods: We have evaluated gait parameters, spasticity, and pain with clinical scales. We have applied focal muscle vibration on quadriceps femoris, hamstrings, gastrocnemius, and iliopsoas muscles bilaterally.
An Interesting Case of Acute Transverse Myelitis Secondary to Hepatitis C and Tricuspid Valve Endocarditis: A Case Report.
Cureus
December 2024
General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to Be University), Pune, IND.
Article Synopsis
- Acute transverse myelitis (ATM) is a serious neurological disorder involving spinal cord inflammation, leading to sensory, motor, and autonomic issues.
- A 29-year-old woman experienced severe lower limb weakness, urinary issues, and sensory loss, with MRI confirming ATM and HCV infection present in her blood.
- The case underscores the need for awareness of ATM as a possible complication of hepatitis C, especially when there is infective endocarditis (IE) involved, as confirmed by blood cultures showing bacteria linked to IE.
Tailored sacroplasty for sacral fracture secondary to an epileptic seizure.
Surg Neurol Int
November 2024
Department of Neurosurgery, Military Medical Academy, Sofia, Bulgaria.
Background: Sacral fractures causing neurological deficits secondary to epileptic seizures are very rare. They are traditionally treated by laminectomy and sacral fixation. However, minimally invasive techniques such as sacroplasty offer more limited surgery with decreased morbidity.
View Article and Find Full Text PDFCharacterization of HTLV-1 Infectious Molecular Clone Isolated from Patient with HAM/TSP and Immortalization of Human Primary T-Cell Lines.
Viruses
November 2024
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.
Article Synopsis
- HTLV-1 is linked to diseases like adult T-cell leukemia and HTLV-1-associated myelopathy, prompting researchers to isolate a molecular clone from a patient with HAM/TSP.
- This clone exhibits unique genetic features and viral mRNA patterns, indicating a potential connection to the development of HAM/TSP.
- The study finds that while direct infection of primary T cells with HTLV-1 clones leads to limited cell growth, transmission from dendritic cells enhances long-term proliferation and supports latent infections.
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