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A novel susceptibility locus to () identified by genetic mapping of automated microscopy computer vision data in grapevines.
Plant Dis
January 2025
State Fruit Experiment Station, Missouri State University, Mountain Grove, Missouri, United States;
Powdery mildew, caused by the fungus , is one of the primary causes of grape yield loss across the globe. While numerous resistance loci have been identified in various grapevine species, the genetic determinants of susceptibility to remain largely unexplored. Understanding the genetics of susceptibility for pathogenesis is equally important for developing durable resistance grapevines against this pathogen.
View Article and Find Full Text PDFMapping snoRNA Targets Transcriptome-Wide with snoKARR-seq.
ACS Chem Biol
January 2025
Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.
Small nucleolar RNAs (snoRNAs) are noncoding RNAs primarily known for guiding chemical modifications of RNA, but their broader cellular roles and contributions to human diseases remain elusive. This In Focus article introduces the development of snoRNA-enriched kethoxal-assisted RNA-RNA sequencing (snoKARR-seq), a transcriptome-wide approach to uncover snoRNA targets with enhanced sensitivity and specificity. This method revealed an unexpected role for snoRNAs in protein translocation and secretion, expanding our understanding of their noncanonical functions.
View Article and Find Full Text PDFMulti-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain.
Nat Genet
January 2025
Division of Computational Biomedicine, Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Tandem repeat (TR) size variation is implicated in ~50 neurological disorders, yet its impact on gene regulation in the human brain remains largely unknown. In the present study, we quantified the impact of TR size variation on brain gene regulation across distinct molecular phenotypes, based on 4,412 multi-omics samples from 1,597 donors, including 1,586 newly sequenced ones. We identified ~2.
View Article and Find Full Text PDFChromosome-level reference genome and annotation of the Arctic fish Anisarchus medius.
Sci Data
January 2025
State Key Laboratory of Mariculture Breeding, Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, College of Marine Sciences, Haixia Institute of Science and Technology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
Anisarchus medius (Reinhardt, 1837) is a widely distributed Arctic fish, serving as an indicator of climate change impacts on coastal Arctic ecosystems. This study presents a chromosome-level genome assembly for A. medius using PacBio sequencing and Hi-C technology.
View Article and Find Full Text PDFSleep stages classification based on feature extraction from music of brain.
Heliyon
January 2025
School of Music, College of Fine Arts, University of Tehran, Tehran, Iran.
Sleep stages classification one of the essential factors concerning sleep disorder diagnoses, which can contribute to many functional disease treatments or prevent the primary cognitive risks in daily activities. In this study, A novel method of mapping EEG signals to music is proposed to classify sleep stages. A total of 4.
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