AI Article Synopsis
Article Abstract
Rationale: In view of the difficulties in using antidepressant agents as training drugs in drug discrimination research, it was reasoned that tianeptine, because of its short duration of action and its lack of toxicity associated with long-term administration, would be well-suited to establish a discriminative stimulus cue in rats and, hence, a valuable tool in the investigation of the neural basis of depression.
Objectives: A drug discrimination procedure was used to determine whether tianeptine was associated with a specific discriminative stimulus effect, and substitution tests were conducted to determine whether this effect was mediated by serotonergic mechanisms.
Method: Rats were trained to discriminate 10 mg/kg tianeptine from saline and were tested with fluoxetine, a selective serotonin (5-HT) reuptake inhibitor; venlafaxine, a 5-HT/noradrenaline reuptake inhibitor; 8-hydroxy-(2-di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT1A agonist; and caffeine, a nonselective antagonist of adenosine receptors.
Results: Tianeptine induced a specific, robust, and sustained discriminative stimulus in rats. Fluoxetine and 8-OH-DPAT partially substituted for tianeptine by producing >50% of tianeptine-appropriate lever responding. In contrast, venlafaxine and caffeine induced responding on a saline-associated lever.
Conclusion: The discriminative stimulus effect of tianeptine is mediated by serotonergic mechanisms, but what is surprising is that this mechanism seems to be, at least partially, enhanced by serotonergic transmission.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00213-005-0210-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Microsaccade selectivity as discriminative feature for object decoding.
iScience
January 2025
School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran 14399-57131, Iran.
Microsaccades, a form of fixational eye movements, help maintain visual stability during stationary observations. This study examines the modulation of microsaccadic rates by various stimulus categories in monkeys and humans during a passive viewing task. Stimulus sets were grouped into four primary categories: human, animal, natural, and man-made.
View Article and Find Full Text PDFDistinct functional cerebral hypersensitivity networks during incisional and inflammatory pain in rats.
Curr Res Neurobiol
June 2025
Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, Germany.
Although the pathophysiology of pain has been investigated tremendously, there are still many open questions with regard to specific pain entities and their pain-related symptoms. To increase the translational impact of (preclinical) animal neuroimaging pain studies, the use of disease-specific pain models, as well as relevant stimulus modalities, are critical. We developed a comprehensive framework for brain network analysis combining functional magnetic resonance imaging (MRI) with graph-theory (GT) and data classification by linear discriminant analysis.
View Article and Find Full Text PDFDistinct detection and discrimination sensitivities in visual processing of real versus unreal optic flow.
Psychon Bull Rev
January 2025
NYU-ECNU Institute of Brain and Cognitive Science, New York University Shanghai, Shanghai, China.
We examined the intricate mechanisms underlying visual processing of complex motion stimuli by measuring the detection sensitivity to contraction and expansion patterns and the discrimination sensitivity to the location of the center of motion (CoM) in various real and unreal optic flow stimuli. We conducted two experiments (N = 20 each) and compared responses to both "real" optic flow stimuli containing information about self-movement in a three-dimensional scene and "unreal" optic flow stimuli lacking such information. We found that detection sensitivity to contraction surpassed that to expansion patterns for unreal optic flow stimuli, whereas this trend was reversed for real optic flow stimuli.
View Article and Find Full Text PDFAccounting for why discrimination between different perceptual contents is not always accompanied conscious detection of that content remains a challenge for predictive processing theories of perception. Here, we test a hypothesis that detection is supported by a distinct inference within generative models of perceptual content. We develop a novel visual perception paradigm that probes such inferences by manipulating both expectations about stimulus content (stimulus identity) and detection of content (stimulus presence).
View Article and Find Full Text PDFDentate gyrus norepinephrine ramping facilitates aversive contextual processing.
Nat Commun
January 2025
Department of Bioengineering, University of Washington, Seattle, WA, USA.
Dysregulation in aversive contextual processing is believed to affect several forms of psychopathology, including post-traumatic stress disorder (PTSD). The dentate gyrus (DG) is an important brain region in contextual discrimination and disambiguation of new experiences from prior memories. The DG also receives dense projections from the locus coeruleus (LC), the primary source of norepinephrine (NE) in the mammalian brain, which is active during stressful events.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!