AI Article Synopsis
- Recent research challenges the traditional view of mitochondrial respiration as simply dependent on oxygen levels and tissue demands.
- Nitric oxide plays a key role in adapting respiratory processes to various physiological conditions and enhances the production of reactive oxygen species for effective NO clearance.
- This interplay between nitric oxide and reactive species impacts cell behaviors such as growth, rest, and death, suggesting a more complex regulation of cell physiology.
Article Abstract
For many years, mitochondrial respiration was thought to follow an "all or nothing" paradigm supporting the notion that in the normal O2 concentration range, respiration is mainly controlled by tissue demands. However, nitric oxide produced by cytosol or mitochondrial nitric oxide synthases adapts respiration to different physiologic conditions and increases the mitochondrial production of O2 active species that contributes to NO clearance. Because mitochondrial NO utilization is sensitive to environmental or hormonal modulation, and because diffusible active species, like H2O2, are able to regulate genes related to proliferation, quiescence, and death, we surmised that the two mechanisms converge to elicit the different responses in cell physiology.
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| http://dx.doi.org/10.1016/S0076-6879(05)96034-5 | DOI Listing |
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