The aim of this study was to determine the developmental changes in the synthesis, storage and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the hypophyseal gonadotroph cells from infancy to peripuberty of ovine ontogeny. An examination has been made in 15 infantile (12-, 15-week-old) and juvenile (22-, 30-week-old) ovary-intact sheep. Histomorphological and functional changes in the adenohypophyseal population of gonadotrophs were assayed with hybridohistochemistry, immunohistochemistry and radioimmunoassay. The percentage of the adenohypophyseal area (PAA) occupied by gonadotrophs containing LHbeta-mRNA or FSHbeta-mRNA was highest (P < 0.05) in the 15-week-old sheep compared with the other stages. The gradual increase in the PAA occupied by immunoreactive (ir)-LHbeta-cells from the 12th to 30th week of age was observed (P < 0.05) and has been interpreted as the increase in the storage of LH. This histomorphological change was accompanied by the gradual increase in the LH pulse frequency from the 15th to 30th week of age (P < 0.05). The PAA occupied by ir-FSHbeta-cells was extremely high in the infantile sheep, and subsequently, low in the juvenile sheep (P < 0.05). Altogether, similar patterns of pretranslational synthesis of the LHbeta- and FSHbeta-subunit but clearly different storage patterns of gonadotrophins were observed. The postnatal development of gonadotrophins seems to be determined by the progressive increase in the storage of LH until peripuberty and by the acute decrease in the storage of FSH during the infantile/juvenile shift. These findings imply the different intrahypophyseal regulation of LH and FSH posttranscriptional processing during the period of transition between infancy and peripuberty in female sheep.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jchemneu.2005.10.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A novel differential display material: KLuSiO: Tb/Bi phosphor with thermal response, time resolution and luminescence color for optical anti-counterfeiting.
J Colloid Interface Sci
February 2022
Coherent Light and Atomic and Molecular Spectroscopy Laboratory, Key Laboratory of physics and Technology for Advanced Batteries, College of Physics, Jilin University, Changchun 130012, China. Electronic address:
Optical anti-counterfeiting and encryption have become a hotspot in information security. However, the advanced optical anti-counterfeiting technology still suffers from low security by single-luminescent mode. Herein, we present a novel multi-mode anti-counterfeiting strategy based on KLuSiO: Tb/Bi (KLSO: Tb/Bi) phosphors for the first time.
View Article and Find Full Text PDFDefect Passivation Effect of Chemical Groups on Perovskite Solar Cells.
ACS Appl Mater Interfaces
August 2022
College of Chemistry, Nanchang University, 999 Xuefu Avenue, Nanchang 330031, China.
Defect passivation is a key strategy to prepare high-performance perovskite solar cells (PVSCs). Even though abundant passivation molecules have been applied, the absence of detailed researches with regard to different functional groups in polymer additives may inevitably impede the establishment of passivation molecules selection rules. In this work, three passivation molecules including poly(vinyl alcohol) (PVA), polymethyl acrylate (PMA), and poly(acrylic acid) (PAA) are employed to systematically analyze the passivation effect from hydroxyl, carbonyl, and carboxyl groups.
View Article and Find Full Text PDFDetermination of chemical species of fluoride during uptake mechanism of glass-ionomer cements with NMR spectroscopy.
Dent Mater
July 2021
Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry, Turner Street, London, UK. Electronic address:
Objective: The aim of the present study was to determine the chemical species formed inside glass-ionomer cements after fluoride uptake and to investigate the depth of penetration of fluoride ions within the cement matrix.
Methods: An experimental fluoride-free glass with composition 2SiO-AlO-CaO was produced. The glass powder was mixed with aqueous poly(acrylic acid) (PAA), and allowed to set.
Water Transport Mechanisms of Poly(acrylic acid), Poly(vinyl alcohol), and Poly(ethylene glycol) in C-S-H Nanochannels: A Molecular Dynamics Study.
J Phys Chem B
July 2020
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau SAR 999078, China.
The transport properties of water molecules in nanochannels are critical to the durability of porous materials. In this article, molecular dynamics simulations are used to study the effects of poly(acrylic acid) (PAA), poly(vinyl alcohol) (PAA), and poly(ethylene glycol) (PEG) on the durability of modified cement-based materials. By establishing ideal composite nanopores, the absorption of water molecules in the channel is simulated.
View Article and Find Full Text PDFExceedingly Small Gadolinium Oxide Nanoparticles with Remarkable Relaxivities for Magnetic Resonance Imaging of Tumors.
Small
October 2019
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, 20892, USA.
Gd chelates have occupied most of the market of magnetic resonance imaging (MRI) contrast agents for decades. However, there have been some problems (nephrotoxicity, non-specificity, and low r ) that limit their applications. Herein, a wet-chemical method is proposed for facile synthesis of poly(acrylic acid) (PAA) stabilized exceedingly small gadolinium oxide nanoparticles (ES-GON-PAA) with an excellent water dispersibility and a size smaller than 2.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!