Oral administration of vanadate is an effective treatment for diabetes in animal models. However, vanadate exerts these effects at high doses and several toxic effects are produced. Low doses of vanadate are relatively safe but are unable to elicit any antidiabetic effect. The present study explored the prospect of using low doses of vanadate in combination with Trigonella seed powder (TSP) to evaluate their antidiabetic effect in alloxan-diabetic rats. Alloxan-diabetic rats were treated with insulin, vanadate, TSP and vanadate and TSP in combination for 3 weeks. The effect of these antidiabetic compounds was examined on general physiological parameters and distribution of glucose transporter (GLUT4) in skeletal muscle by immunoblotting and immunohistochemistry. Treatment of alloxan-diabetic rats with insulin, vanadate, TSP and vanadate in combination with TSP revived normoglycemia and restored the disturbances in the distribution of GLUT4 in skeletal muscle. TSP treatment was only partially effective in the restoration of diabetic alterations. The treatment of diabetic rats with combined doses of vanadate and TSP was most effective in the normalization of plasma glucose levels and correction of altered GLUT4 distribution.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.lfs.2005.05.105 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of vildagliptin conjugated monometallic nanoparticles and bimetallic nanocomposites on diabetes-induced cognitive deficit.
Exp Neurol
January 2025
School of Pharmaceutical Sciences, Siksha' O'Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.
Article Synopsis
- * The research focuses on the potential protective effects of vildagliptin (VLD) and its nanoparticles against oxidative stress-induced brain damage, with various nanoparticles synthesized and evaluated for their effectiveness.
- * Results indicated that both VLD and its nanoformulations showed significant antioxidant properties, improving brain health in diabetic rats, with the bimetallic Se@Au nanoparticles providing the most protection.
Hypoglycemic and hypolipidemic effects of Kunth in diabetic rats.
Food Sci Nutr
July 2024
Research, Teaching and Extension Laboratory in Clinical Analysis, Institute of Biological Sciences Federal University of Pará Belém Brazil.
Diabetes mellitus is a metabolic disorder commonly associated with atherosclerosis. Plants with therapeutic potential, such as Kunth, emerge as effective alternatives for treating these diseases. Therefore, this work aims to analyze the antihyperglycemic and antidyslipidemic potential of the hydroalcoholic extract of Kunth (ELo) in alloxan-diabetic rats.
View Article and Find Full Text PDFMolecular Modeling, Synthesis, and Antihyperglycemic Activity of the New Benzimidazole Derivatives - Imidazoline Receptor Agonists.
Drug Des Devel Ther
April 2024
SUNY Downstate Medical Center / University Hospital of Brooklyn, New York, NY, USA.
Introduction: The paper presents the results of a study on the first synthesized benzimidazole derivatives obtained from labile nature carboxylic acids. The synthesis conditions of these substances were studied, their structure was proved, and some components were found to have sugar-reducing activity on the model of alloxan diabetes in rats.
Methods: The study used molecular modeling methods such as docking based on the evolutionary model (igemdock), RP_HPLC method to monitor the synthesis reaction, and 1H NMR and 13C NMR, and other methods of organic chemistry to confirm the structures of synthesized substances.
Antioxidant properties of date seeds extract (Phoenix dactylifera L.) in alloxan induced damage in rats.
Braz J Biol
December 2023
University of Gafsa, Faculty of Sciences of Gafsa, Laboratory of Biotechnology and Biomonitoring of the Environment and Oasis Ecosystems - LBBEEO, Gafsa, Tunisia.
The study was conducted to examine the antioxidant activity and evaluate the protective effects of the date seeds powder kentichi against alloxan-induced damage in the liver, kidney, and pancreas in diabetic's rats. Group 1: control group, that did not receive any treatment, Group 2: alloxan was injected intraperitoneally (120 mg/kg body weight) for two days (Diab), Group 3: treated only by date seeds powder added in the diet (300 g/kg) for 6 weeks (DSPK), Group 4: alloxan-diabetic rats treated with date seeds powder (300 g/kg) (DSPK + Diab). Estimations of biochemical parameters in blood were determined.
View Article and Find Full Text PDFRutin ameliorates nitrergic and endothelial dysfunction on vessels and corpora cavernosa of diabetic animals.
Res Vet Sci
August 2023
Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Ceará, Brazil.. Electronic address:
Endothelial dysfunction is an early complication of diabetes and it is related to both micro- and macroangiopathies. In addition, >70% of diabetic patients develop autonomic neuropathies. Increased oxidative stress has a major role in the development of both nitrergic and endothelial dysfunction.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!