[reaction: see text] Alpha-nitro ketones can be transformed selectively into trialkyl-substituted pyrazines via reaction with alpha-amino ketones using octyl viologen as an electron-transfer reagent. The new synthetic method, and the optimal reaction conditions that allow for the regiochemical control, are described.
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Facile regiocontrolled synthesis of trialkyl-substituted pyrazines.
Org Lett
November 2005
Department of Chemistry, Idaho State University, Campus Box 8023, Pocatello, Idaho 83209, USA.
[reaction: see text] Alpha-nitro ketones can be transformed selectively into trialkyl-substituted pyrazines via reaction with alpha-amino ketones using octyl viologen as an electron-transfer reagent. The new synthetic method, and the optimal reaction conditions that allow for the regiochemical control, are described.
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