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Inside-out submitochondrial particles affect the mitochondrial permeability transition pore opening under conditions of mitochondrial dysfunction.
Biochim Biophys Acta Bioenerg
January 2025
Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, Italy. Electronic address:
The inside-out submitochondrial particles (IO-SMPs) showed a strong protective effect against mitochondrial permeability transition pore (mPTP) opening in mitochondria isolated from swine hearts 3 h after explantation. The latter condition was used to emulate situation of mitochondrial damage. We identified that the protective effect of IO-SMPs cannot be attributed to a functional modulation of the enzymatic complexes involved in mPTP formation.
View Article and Find Full Text PDFAugmented reality guidance improves accuracy of orthopedic drilling procedures.
Sci Rep
October 2024
Department of Orthopedic Surgery and Traumatology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090, Brussels, Belgium.
In several orthopedic procedures, the accurate use of surgical power tools is critical to avoid damage to surrounding tissues. As such, various guidance techniques and safety measures were developed. Augmented reality (AR) guidance shows promise but requires validation.
View Article and Find Full Text PDFInside-Out Rational Design of Ornithine Cyclodeaminase OCD from by a Multiregion Synergy Strategy for Efficient Synthesis of l-Pipecolic Acid.
J Agric Food Chem
November 2024
State Key Laboratory of Bioreactor Engineering New World Institute of Biotechnology, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China.
Lysine cyclodeaminase (LCD)-mediated synthesis of l-pipecolic acid (l-PA) from l-lysine (l-Lys) is a promising approach. However, only one LCD has been reported, and its inadequate activity limits industrial applications. To address this problem, a substrate analogue-guided enzyme mining strategy was employed.
View Article and Find Full Text PDFCase report: Advances in treating ligyrophobia with third-generation ACT approach.
Front Psychiatry
September 2024
Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Background And Aims: Giulia, an 11-year-old girl diagnosed with ligyrophobia, has been experiencing intense anxiety related to loud noises since the age of two. This case report aims to explore the efficacy of Third-Wave Cognitive Behavioral Therapy, specifically Acceptance and Commitment Therapy (ACT), in addressing Giulia's anxiety and avoidance behaviors. The primary goal is to examine the impact of ACT on reducing ligyrophobic symptoms and enhancing psychological flexibility.
View Article and Find Full Text PDFPrion protein prevents the inhibition of large-conductance calcium-activated potassium channel by Tau peptide K18 oligomers.
Biochem Biophys Res Commun
November 2024
Nencki Institute of Experimental Biology of Polish Academy of Sciences, 3 Pasteur Str., 02-093, Warsaw, Poland. Electronic address:
Alzheimer's disease (AD) is a tauopathy characterized by the deposition of amyloid aggregates of hyperphosphorylated Tau protein and amyloid-β peptide (Aβ) in the brain. Nevertheless, a soluble, oligomeric forms of Tau and Aβ are considered to be the most neurotoxic species responsible for neurodegenerative processes in AD. The mechanism of action of these oligomers remains largely unclear.
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