The implantation in pig is superficial and non-invasive, involving phases of apposition, adhesion and attachment of conceptuses to endometrial surface epithelium. The role of integrins and ECM proteins is suggested. In the study, the expression of beta5beta1 integrin and FN on conceptus trophectoderm and endometrium during implantation and early pregnancy was investigated. The immunohistochemical localization of alpha5beta1 integrin and FN was performed on formalin-fixed, paraffin-embedded tissue sections using the ABC method. The results indicate that both conceptus and uterus expressed alpha5beta1 integrin and FN during early porcine pregnancy. The most intensive staining for alpha5beta1 integrin and FN was found in conceptus trophectoderm and endometrial surface epithelium in all investigated periods. During placentation the immunohistochemical staining for both alpha5beta1 integrin and FN was increased in trophectoderm and all endometrial structures. Since placenta in pigs is non-invasive, it can be suggested that both alpha5beta1 integrin and FN participate in molecular events leading to successful implantation and placentation in species with true epitheliochorial placenta.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Phosphorylation of endothelial histone H3.3 serine 31 by PKN1 links flow-induced signaling to proatherogenic gene expression.
Nat Cardiovasc Res
January 2025
Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
Atherosclerotic lesions develop preferentially in arterial regions exposed to disturbed blood flow, where endothelial cells acquire an inflammatory phenotype. How disturbed flow induces endothelial cell inflammation is incompletely understood. Here we show that histone H3.
View Article and Find Full Text PDFSPP1-ITGα5/β1 Accelerates Calcification of Nucleus Pulposus Cells by Inhibiting Mitophagy via Ubiquitin-Dependent PINK1/PARKIN Pathway Blockade.
Adv Sci (Weinh)
December 2024
Department of Orthopedic, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
Low back pain (LBP) caused by nucleus pulposus degeneration and calcification leads to great economic and social burden worldwide. Unexpectedly, no previous studies have demonstrated the association and the underlying mechanism between nucleus pulposus tissue degeneration and calcification formation. Secreted Phosphoprotein 1 (SPP1) exerts crucial functions in bone matrix mineralization and calcium deposition.
View Article and Find Full Text PDFThe novel ECM protein SNED1 mediates cell adhesion via the RGD-binding integrins α5β1 and αvβ3.
J Cell Sci
December 2024
Department of Physiology and Biophysics, University of Illinois Chicago, Illinois, 60612, USA.
The extracellular matrix (ECM) is a complex meshwork comprising over 100 proteins. It serves as an adhesive substrate for cells and, hence, plays critical roles in health and disease. We have recently identified a novel ECM protein, SNED1, and have found that it is required for neural crest cell migration and craniofacial morphogenesis during development and in breast cancer, where it is necessary for the metastatic dissemination of tumor cells.
View Article and Find Full Text PDFO-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner.
Neuro Oncol
December 2024
Department of Neurosurgery, Qilu Hospital of Shandong University, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan 250012, Shandong, China.
Background: Interactions between mesenchymal glioblastoma stem cells (MES GSCs) and myeloid-derived macrophages (MDMs) shape the tumor-immunosuppressive microenvironment (TIME), promoting the progression of glioblastoma (GBM). N6-methyladenosine (m6A) plays important roles in the tumor progression. However, the mechanism of m6A in shaping the TIME of GBM remains elusive.
View Article and Find Full Text PDFEndothelial Angpt2 Promotes Adipocyte Progenitor Cells Maturation to Increase Visceral Adipose Tissue Accumulation.
Diabetes Metab Res Rev
January 2025
Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Aims: Visceral adipose tissue (VAT) accumulation is essential for the occurrence and development of obesity and related metabolic diseases. Currently, the specific mechanism of VAT accumulation is still unclear.
Materials And Methods: We searched the Gene Expression Omnibus database to obtain single-cell RNA sequencing (scRNAseq) data for VAT in patients with a normal body mass index (BMI), obesity, or morbid obesity.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!