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Efficacy of Bilastine, Dextromethorphan, and Phenylephrine Syrup in Patients With Dry Cough: A Phase 3 Randomised Trial.
Cureus
December 2024
Research and Development, Glenmark Pharmaceuticals Limited, Mumbai, IND.
Background Cough in common cold is often associated with rhinorrhoea and nasal congestion, requiring treatment with a cough suppressant, decongestant, and antihistamine. Bilastine is a non-sedating antihistamine, a preferred option over sedating antihistamines. A combination of bilastine, dextromethorphan, and phenylephrine is expected to provide non-sedating treatment for cough associated with a common cold or allergy.
View Article and Find Full Text PDFVasorelaxant effect of fennel seeds (Foeniculum vulgare Mill) extracts on rat mesenteric arteries: Assessment of phytochemical profiling and antioxidant potential.
Fitoterapia
December 2024
Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health. Faculty of Sciences, Mohammed First University, Oujda, BP-717, 60000 Oujda, Morocco. Electronic address:
Ethnopharmacological Relevance: Hypertension is a serious health problems and a leading cause of adult mortality worldwide. Foeniculum. vulgare Mill, a plant traditionally used for various ailments, including cardiovascular disorders such as hypertension.
View Article and Find Full Text PDFDecreased blood pressure with acute administration of quercetin in L-NAME-induced hypertensive rats.
Basic Clin Pharmacol Toxicol
January 2025
Wits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear. We investigated the acute effects of quercetin on BP, aortic mechanical properties and vascular reactivity in female Sprague-Dawley (SD) rats. Hypertension was induced using L-NAME (40 mg/kg/day).
View Article and Find Full Text PDFCarob leaves: Phytochemistry, antioxidant properties, vasorelaxant effect and mechanism of action.
J Ethnopharmacol
January 2025
Laboratory of Bioresources, Biotechnologies, Ethnopharmacology and Health, Department of Biology, Faculty of Sciences, University Mohammed First, Oujda, 60000, Morocco. Electronic address:
Ethnopharmacological Relevance: Ceratonia siliqua L., is a species of significant nutritional and industrial interest with extensive traditional uses. This fabaceae is renowned for its medicinal properties, including the treatment of high blood pressure.
View Article and Find Full Text PDFTranscription Factor 21 Regulates Cardiac Myofibroblast Formation and Fibrosis.
Circ Res
January 2025
Division of Molecular Cardiovascular Biology (A.K.Z.J., R.K.K., R.J.V., S.-C.J.L., S.L.K.B., Y.K., K.M.G., K.W., M.A.S., T.A.B., J.D.M.), Department of Pediatrics, University of Cincinnati and Cincinnati Children's Hospital Medical Center, OH.
Background: TCF21 (transcription factor 21) is a bHLH (basic helix-loop-helix) protein required for the developmental specification of cardiac fibroblasts (CFs) from epicardial progenitor cells that surround the embryonic heart. In the adult heart, TCF21 is expressed in tissue-resident fibroblasts and is downregulated in response to injury or stimuli leading to myofibroblast differentiation. These findings led to the hypothesis that TCF21 regulates fibroblast differentiation in the adult mammalian heart to affect fibrosis.
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