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Nasal effects of a mixture of volatile organic compounds and their ozone oxidation products. | LitMetric
Objective : Our objective was to determine if low levels of a mixture of volatile organic compounds (VOCs) and their ozone (O3) oxidation products, similar to what might be found in "sick buildings," cause nasal irritation and inflammation under controlled exposure conditions.Methods : Healthy, nonsmoking women (n=130) completed 2-hour controlled exposures to VOCs, VOCs and O3, and a masked air "MA" control in random order at least 1 week apart. VOCs and O3 concentrations were approximately 25 mg/m and approximately 40 ppb, respectively. Nasal symptoms were rated before, during, and after exposure. Nasal lavage fluid was analyzed for polymorphonuclear cells, total protein, interleukin-6, and interleukin-8.Results : We found no significant differences in symptoms or markers of nasal inflammation between exposure conditions.Conclusions : Results suggest that VOCs and their oxidation products may not cause acute nasal effects at low concentrations.
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