Background: Many authors have speculated that altered neuromuscular control and strength of the lower extremity are responsible for the gender disparity in knee ligament injury rates.
Hypothesis: Significant increases in normalized quadriceps and hamstrings strength and limb symmetry on single-legged hop test occur with age. No gender differences in strength occur until age 14 years, after which boys generate greater peak torques than do girls. Age and gender do not influence lower limb alignment on a drop-jump test.
Study Design: Cross-sectional study; Level of evidence, 3.
Methods: We studied the effects of age and gender in 1140 athletes, 9 to 17 years old, on muscle strength and neuromuscular control during functional activities. Isokinetic quadriceps and hamstrings strength was measured at 300 deg/s. Limb symmetry was assessed with single-legged hop tests. A video drop-jump test determined lower limb alignment in the coronal plane.
Results: Extension peak torques significantly increased with age; maximum strength was noted in girls at age 13 years and in boys at age 14 years (P < .001). Although maximum flexion strength occurred in boys at age 14 years (P < .001), girls had only slight increases from ages 9 to 11 years (P = not significant). Boys aged 14 to 17 years had significantly greater normalized isokinetic strength than did age-matched girls. No age or gender effects existed in limb alignment on the drop-jump test or limb symmetry on single-legged hop testing.
Conclusion: Maximum hamstrings strength was noted in female athletes by age 11 years, compared with age 14 years in male athletes, and a distinct lower limb valgus alignment existed in the majority of all athletes on landing. The absence of a gender difference in lower limb alignment on landing suggests other factors may be responsible for the gender disparity in knee ligament injury rates.
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http://dx.doi.org/10.1177/0363546505281242 | DOI Listing |
Int J STD AIDS
March 2025
MAP Centre for Urban Health Solutions, St. Michael's Hospital, Toronto, ON, Canada.
BackgroundHepatitis B virus (HBV) disproportionately affects people at risk of HIV. Encounters for HIV post-exposure prophylaxis (PEP) create opportunities for HBV screening and prevention. We quantified HBV prevalence, susceptibility, and active/passive immunization use among patients seeking HIV PEP.
View Article and Find Full Text PDFJ Med Internet Res
March 2025
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Background: Hypertension is a major global health issue and a significant modifiable risk factor for cardiovascular diseases, contributing to a substantial socioeconomic burden due to its high prevalence. In China, particularly among populations living near desert regions, hypertension is even more prevalent due to unique environmental and lifestyle conditions, exacerbating the disease burden in these areas, underscoring the urgent need for effective early detection and intervention strategies.
Objective: This study aims to develop, calibrate, and prospectively validate a 2-year hypertension risk prediction model by using large-scale health examination data collected from populations residing in 4 regions surrounding the Taklamakan Desert of northwest China.
Epilepsia
March 2025
University of California San Francisco Weill Institute for Neurosciences, Benioff Children's Hospital, San Francisco, California, USA.
Objective: We analyzed the long-term safety and effectiveness of fenfluramine (FFA) in patients with Dravet syndrome (DS) in an open-label extension (OLE) study after participating in randomized controlled trials (RCTs) or commencing FFA de novo as adults.
Methods: Patients with DS who participated in one of three RCTs or were 19 to 35 years of age and started FFA de novo were included. Key endpoints were: incidence of treatment-emergent adverse events (TEAEs) in the safety population, and median percentage change in monthly convulsive seizure frequency (MCSF) from the RCT baseline to end of study (EOS) in the modified intent-to-treat (mITT) population.
Dermatol Reports
February 2025
Division of Regenerative and Oncological Dermatological Surgery, Modena University Hospital.
In patients with epidermolysis bullosa (EB), surgery may be required to remove squamous cell carcinoma (SCC) of the hands or to correct pseudo-syndactyly. Dermal substitutes may represent a suitable tool to promote the healing of surgical wounds in EB. We review our experience with a collagen-elastin dermal matrix to promote surgical wound healing due to hand surgery to correct pseudo-syndactyly or SCC resection in patients affected by EB.
View Article and Find Full Text PDFJAMA Cardiol
March 2025
Department of Cardiovascular Medicine and Section on Geriatrics and Gerontology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Importance: Excess body fat plays a pivotal role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). HU6 is a novel, controlled metabolic accelerator that enhances mitochondrial uncoupling resulting in increased metabolism and fat-specific weight loss.
Objective: To assess efficacy and safety of HU6 in reducing body weight, improving peak volume of oxygen consumption (VO2) and body composition among patients with obesity-related HFpEF.
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