AI Article Synopsis
- Toxic epidermal necrolysis is usually triggered by medication use and is primarily diagnosed through pathological methods.
- A case is presented of a female patient who experienced severe skin issues after taking clarithromycin for tonsillitis.
- The study details how to determine the link between a drug and the immune reaction using a recognized assessment framework.
Article Abstract
Toxic epidermal necrolysis almost always occurs after taking a medication. Despite spectacular clinical signs, it is mainly diagnosed with pathologic techniques. The identification of a drug as the cause for the immune related cytotoxic reaction can be difficult if the molecule is not generally known to be a classical cause of this reaction. The present study describes a female patient who rapidly developed a severe bullous skin disease after taking clarithromycin for tonsillitis. The case illustrates the process involved in attributing causality to a molecule using an established imputability assessment framework.
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