The value of electromyography (EMG) in the interpretation of normal and pathological movement depends on recording, processing, and normalization procedures. Traditionally, maximum voluntary isometric contraction (MVIC) of individual muscles is commonly used for EMG normalization. However, this is a time- and energy-consuming procedure, especially in patients. The aim of the present study was to compare an alternative method of recording the MVIC of lower-limb muscles to the traditional method in healthy, young subjects as well as individuals with a stroke. The alternative method consisted of recording the maximum effort of several thigh and leg muscles simultaneously using two tasks on a dynamometer. Five healthy subjects and five individuals who had a stroke performed both MVIC tasks. The healthy group repeated the test 3 h later on the same day. In general, the method of computing maximum EMG from the alternative MVIC test yielded values that were equal or greater than those from the traditional test in both groups. In the healthy group, muscles showed similar EMGs in the two sessions, indicating that the test was reliable. These results suggest that the less time-consuming alternative method of computing maximum EMG values used here provides a reasonable alternative when time and fatigue become issues, especially when testing patient populations.
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http://dx.doi.org/10.1002/mus.20458 | DOI Listing |
Clin Nucl Med
November 2024
From the Interventional Oncology/Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY.
Background: Radiation segmentectomy (RS) is an alternative potential local curative treatment for selected colorectal liver metastases (CLMs) not amenable to ablation or limited resection.
Purpose: The aim of this study was to evaluate the dosimetric response of low volume CLMs to RS in heavily pretreated patients who are not candidates for resection or percutaneous ablation.
Patients And Methods: This single-center retrospective study evaluated CLMs patients treated with RS (prescribed tumor dose >190 Gy) from 2015 to 2023.
Methods Mol Biol
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Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain.
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View Article and Find Full Text PDFCerebellum
January 2025
Department of Neuroscience and Physiology, Grossman School of Medicine, NYU Neuroscience Institute, New York University, New York, NY, 10016, USA.
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View Article and Find Full Text PDFMethods Mol Biol
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Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
The HOX and PBX genes encode transcription factors that have key roles in development and cancer, both independently and as a heterodimer within a complex of proteins that recognizes specific sequences in DNA and can both activate and repress transcription of target genes. Due to functional redundancy amongst HOX proteins, knock down or knock out studies of individual genes often do not result in an altered phenotype. An alternative approach is to target the interaction between HOX and PBX proteins, which is dependent on a conserved hexapeptide region within HOX.
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