Data on the retrospective analysis of 245 cases of endoprosthetic replacement of bones and major joints are presented. Intraprosthetic infection-related complications were reported in 11%. They developed within 3 months in 64% and their frequency was significantly higher in cases of repeat surgery, resection of proximal tibia with subsequent endoprosthetic replacement of defective knee joint as well as adjuvant polychemotherapy. Anti-infective treatment alone was effective in 11%; complications were aborted by means of surgery of varying extent in 75%.
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