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Alleviating vascular calcification with Bushen Huoxue formula in rats with chronic kidney disease by inhibiting the PTEN/PI3K/AKT signaling pathway through exosomal microRNA-32.
J Pharm Pharmacol
October 2024
Department of Nephrology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Article Synopsis
- Vascular calcification (VC) is a serious issue in patients with chronic kidney disease (CKD) that can lead to increased cardiovascular mortality, mainly due to the transformation of vascular smooth muscle cells (VSMCs) into osteoblast-like cells influenced by exosomes and microRNAs.
- The study explored the effects of the Bushen Huoxue (BSHX) formula on VC using both in vitro models with high phosphate and an in vivo CKD-VC rat model, examining various biochemical and cellular markers related to calcification.
- Results showed that exosomal miRNA-32 plays a significant role in VC development and that the PI3K/AKT signaling pathway is involved, suggesting a potential therapeutic mechanism of
Histopathological lesions of the gastrointestinal tract associated with the use of polystyrene sulfonate and sevelamer: a meta-analysis.
Pathologica
August 2024
Department of Medicine and Surgery, University of Parma, Parma, Italy.
Article Synopsis
- Gastrointestinal severe adverse events like ulceration and perforation have been linked to polystyrene sulfonate and sevelamer, especially in patients with chronic kidney disease, but the exact cause is unclear.* -
- A meta-analysis of existing research found that polystyrene sulfonate is significantly more likely to cause severe issues such as necrosis or perforation compared to sevelamer (p < 0.001).* -
- The findings indicate that while sevelamer may cause inflammation or ulceration, polystyrene sulfonate is more strongly associated with severe outcomes, including a higher risk of death (p < 0.001).*
A Sole Case of the FGF23 Gene Mutation c.202A>G (p.Thr68Ala) Associated with Multiple Severe Vascular Aneurysms and a Hyperphosphatemic Variant of Tumoral Calcinosis-A Case Report.
Life (Basel)
May 2024
Department of Urology and General Medicine, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Tumoral calcinosis is an extremely rare genetic disease caused by mutations in three genes, GALNT3, FGF23, and KL, which disrupt phosphorus metabolism. The hallmark of this condition is the formation of tumors in the soft tissues around the joints. Other phenotypic features of tumoral calcinosis are dental involvement and brain and vascular calcifications.
View Article and Find Full Text PDFAssociation of Sevelamer Initiation with Gastrointestinal Bleeding Hospitalization in Individuals Requiring Hemodialysis.
Am J Nephrol
August 2024
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Introduction: Case reports have suggested a causative role between sevelamer use and subsequent gastrointestinal bleeding (GIB), but no large observational studies have evaluated this association.
Methods: Using the United States Renal Data System database from 2015 to 2019, we examined the association between initiation of sevelamer (vs. non-sevelamer containing phosphate binders) and GIB hospitalization as well as all-cause mortality among individuals on hemodialysis.
Sevelamer Use and Mortality in People with Chronic Kidney Disease Stages 4 and 5 Not on Dialysis.
J Clin Med
December 2023
Department of Medicine, Universitat de València, 46010 Valencia, Spain.
Data suggest that non-calcium-based binders, and specifically sevelamer, may lead to lower rates of death when compared with calcium-based binders in end-stage renal disease (ESRD) patients. However, the association between sevelamer use and mortality for those with non-dialysis-dependent chronic kidney disease (NDD-CKD) patients has been uncertain. Our research is presented in a prospective cohort study.
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