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Twelve compounds were isolated from the MeOH extract of the leaf and stem of the Korean endemic plant Weigela subsessilis L. H. Bailey. Their chemical structures were elucidated on the basis of physicochemical and spectroscopic data and by comparison with those of published literatures. These compounds were identified as three sterols, beta-sitosterol acetate (2), betasitosterol (3), daucosterol (11), eight triterpenoids, squalene (1), ursolic acid (4), ilekudinol A (5), corosolic acid (6), ilekudinol B (7), esculentic acid (8), pomolic acid (9), asiatic acid (10), and one iridoid glycoside, alboside I (12). This is the first report pertaining to the isolation of these compounds from Weigela subsessilis L. H. Bailey. In addition, three compounds 7, 9, and 12 were found to display a strong inhibitory effect on the production of IL-8 in the HT29 cells stimulated by TNF-alpha.
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http://dx.doi.org/10.1007/BF02972975 | DOI Listing |
Front Plant Sci
October 2024
College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang, China.
Thunb. is a genus in the family Caprifoliaceae. All species in this genus have high ornamental and medicinal value.
View Article and Find Full Text PDFPlants (Basel)
August 2021
Jeonju AgroBio-Materials Institute, Jeonju-si 54810, Jeollabuk-do, Korea.
is used in folk medicine to treat pain and allergic syndromes in Korea. However, the antibacterial and anti-inflammatory activities of callus extract remain unexplored. In this study, we aimed to evaluate the callus of pharmacological activity.
View Article and Find Full Text PDFArch Pharm Res
August 2015
Biomolecular Science, University of Science and Technology, UST, Daejeon, 305-806, Korea.
Three new triterpene glycosides (Lonicerosides K, L and M) and 11 known compounds were isolated from the aerial parts of Weigela subsessilis. Among the known isolated compounds, loniceroside A, sweroside, kaempferol-3-O-glucopyranoside 6″-(3-hydroxy-3-methylglutarate), kaempferol-3-O-acetylglucoside and grandifloroside were reported for the first time in a Weigela genus plant. Their chemical structures were identified using extensive spectroscopic analysis including two-dimensional (2D)-NMR experiments, HR-ESI-QTOF-MS and comparison with reported data.
View Article and Find Full Text PDFPhytother Res
November 2010
College of Pharmacy, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Korea.
During the screening effort to discover new types of protein tyrosine phosphatase 1B (PTP1B) inhibitors, it was found that a MeOH extract of the leaves and stems of Weigela subsessilis (Caprifoliaceae) inhibited the enzyme activity. By means of an in vitro bioassay-guided fractionation on the MeOH extract, two 24-norursane triterpenes, ilekudinol A (1) and ilekudinol B (2), were isolated as active metabolites. Compounds 1 and 2 inhibited PTP1B with IC(50) values of 29.
View Article and Find Full Text PDFPhytother Res
December 2010
Regional Cancer Institute, Chungnam National University Hospital, Daejeon, Korea.
Corosolic acid is one of the triterpenoids present in the leaves of Weigela subsessilis. The antidiabetic activity of corosolic acid has been reported previously, but to date, the anticancer effects on gastric cancer have been poorly studied. In this study, corosolic acid showed growth inhibition on SNU-601 human gastric cancer cells, with an IC₅₀ value of 16.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!