The aim of this article was to present a simple classification of phytoestrogens, their approximate content in food products as well as their synthesis, biotransformation and activity in human organism. Having various mechanisms of action, phytoestrogens display both beneficial and adverse effects on physiological processes. Several positive health effects have been associated with phytoestrogens, such as a protective role against the development of cancers, proestrogenic effects (particularly with postmenopausal women) and beneficial influence on cardiovascular and osseous systems. Adverse effects of phytoestrogens have been observed in fetuses and young specimens. Limited studies have displayed disorders in morphology and physiology of the male reproductive system. High plasma phytoestrogens level inhibits a cellular activity of some enzymes, e.g. enzymes involved in the synthesis of steroid hormones. Direct contact with exogenous, environmental estrogens depends on human diet and it can be variable in different populations.
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Clinics (Sao Paulo)
January 2025
Department of Hematology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. Electronic address:
Background: The common drugs used for the treatment of Newly Diagnosed Multiple Myeloma (NDMM) include bortezomib and lenalidomide, but the adverse effects of lenalidomide cannot be ignored, especially when it is used in the initial therapy.
Methods: This retrospective study evaluated the efficacy and safety of a modified DVD regimen (pegylated liposomal doxorubicin, bortezomib, and dexamethasone) followed by lenalidomide in the treatment of NDMM. A total of 40 NDMM patients were treated with a reduced dose of pegylated liposomal doxorubicin (20 mg/m) on day 1, subcutaneous bortezomib (1.
Brucellosis, caused by a facultative intracellular gram-negative coccobacillus, is one of the most common zoonotic infections worldwide. Very rarely, brucellosis can cause periprosthetic joint infections (PJI). In this case-based literature review, we summarize the current medical literature regarding Brucella PJI, with the aim to raise awareness among clinicians, particularly in non-endemic areas.
View Article and Find Full Text PDFActa Orthop Belg
December 2024
Chryseobacterium indologenes is a rare human pathogen which is nowadays considered an emerging fearsome organism because of its upcoming antibiotic resistance. We present a quite unique case of a multi drug resistant C. indologenes surgical wound infection in a patient submitted to cannulated screw fixation of a displaced medial malleolus fracture.
View Article and Find Full Text PDFDislocation is the second most common indication for revision total hip arthroplasty (THA). In revision cases the dislocation rate can be as high as 5-30%. The aim of this study was to assess the outcome, specifically the dislocation rate in revision THA where a dual mobility cup was used.
View Article and Find Full Text PDFAustralas J Ageing
March 2025
Department of Physiotherapy, Faculty of Health Sciences, International Hellenic University - Alexander Campus, Thessaloniki, Greece.
Objectives: To determine the safety and efficacy of a video-supported Cawthorne-Cooksey exercise program (CCEP) in improving balance, dizziness and decreasing fear of falling in older adults with balance deficits and dizziness.
Methods: Thirty-two older adults were divided into two groups (intervention and control). The intervention group followed a video-supported CCEP group, while the control group received written instructions to maintain their usual activity and counselling on fall prevention.
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