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Activators of the 26S proteasome when protein degradation increases.
Exp Mol Med
January 2025
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115, USA.
In response to extra- and intracellular stimuli that constantly challenge and disturb the proteome, cells rapidly change their proteolytic capacity to maintain proteostasis. Failure of such efforts often becomes a major cause of diseases or is associated with exacerbation. Increase in protein breakdown occurs at multiple steps in the ubiquitin-proteasome system, and the regulation of ubiquitination has been extensively studied.
View Article and Find Full Text PDFThe protein ingredient quality of infant formula influences colonic physiology and microbiota and the serum metabolomic profile in neonatal mini-piglets.
Food Res Int
January 2025
Institut NuMeCan, INRAE, INSERM, Univ Rennes, Saint Gilles, France. Electronic address:
Despite the WHO recommendations in favor of breastfeeding, most infants receive infant formulas (IFs), which are complex matrices involving numerous ingredients and processing steps. Our aim was to understand the impact of the quality of the protein ingredient in IFs on gut microbiota and physiology, blood metabolites and brain gene expression. Three IFs were produced using whey proteins (WPs) from cheese whey (IF-A) or ideal whey (IFs-C and -D) and caseins, either in a micellar form (IFs-A and -C) or partly in a non-micellar form (IF-D).
View Article and Find Full Text PDFBench scale Layer-by-Layer microencapasulation of Lactiplantibacillus plantarum WCFS1.
Food Res Int
January 2025
Center for Research and Development in Food Cryotechnology (CIDCA, CCT-CONICET), La Plata 1900, Argentina. Electronic address:
Layer-by-Layer (LbL) self-assembly encapsulation is a promising technology for the protection and delivery of lactic acid bacteria. However, laboratory-scale encapsulation is often time-consuming, involves intensive protocols tailored for small-scale operations, requires substantial amounts of energy and water, and results in a low yield of encapsulated biomass. Scaling-up this process to a bench-bioreactor scale is not simply a matter of increasing culture volume as different key parameters (not particularly relevant at lab scale) become critical, including biomass production, the number of polymer layers, and the biomass-to-polymer mass ratio.
View Article and Find Full Text PDFNeural Determinants of Sedentary Lifestyle in Older Adults: A Brain Network Analysis.
Brain Behav
January 2025
Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA.
Purpose: The prevalence of sedentary lifestyles (SL), which includes both high volumes of extended sitting behavior and a low volume of steps accumulated across the day, among older adults continues to rise contributing to increases in associated comorbidities and the loss of independence. The social, personal, and economic burdens are enormous. In recognition of the health implications of SL, current public health physical activity guidelines now emphasize the complimentary goals of sitting less by moving more.
View Article and Find Full Text PDFViews and Experiences of Nurses Receiving Care as Inpatients: An Empirical Qualitative Study From Ankara.
Nurs Open
January 2025
Faculty of Nursing, Hacettepe University, Ankara, Türkiye.
Aim: To determine the views and experiences of inpatient nurses receiving care.
Background: Switching from the care provider role to being a patient allows nurses to realise patients' real care expectations and to test their colleagues' care practices. Nurses' experience as inpatients is essential for understanding patients' care-related expectations and improving care quality by reflecting on their practices.
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