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Orally administered prednisolone decreases plasma arginine vasopressin and serum copeptin concentrations in healthy dogs.
J Vet Intern Med
January 2025
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Background: The pathophysiology of polyuria and polydipsia secondary to exogenous glucocorticoid excess is incompletely understood.
Objective: Investigate plasma AVP (pAVP) and serum CoP (sCoP) concentrations in healthy dogs before, during, and after abrupt discontinuation of a long-term course of orally administered prednisolone.
Animals: Eight healthy neutered young adult research Beagles.
Copeptin as biomarker for acute ischemic stroke prognosis and revascularization treatment efficacy.
Front Neurol
December 2024
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Introduction: Pro-arginine vasopressin consists of three peptides: . AVP is released by the neurohypophysis in response to increased plasma osmolality, decreased blood volume and stress. Copeptin has the advantage of being stable ex vivo and easy to measure.
View Article and Find Full Text PDFSelf-assembly, cytocompatibility, and interactions of desmopressin with sodium polystyrene sulfonate.
Soft Matter
December 2024
Departamento de Biofísica, Universidade Federal de São Paulo, São Paulo 04062-000, Brazil.
Peptide-polymer systems hold strong potential for applications in nanotherapeutics. Desmopressin, a synthetic analogue of the antidiuretic hormone arginine vasopressin, may serve as a valuable case of study in this context since it is a first-line treatment for disorders affecting water homeostasis, including diabetes insipidus. It also has an established use as a hemostatic agent in von Willebrand disease, and recently, its repurposing has been suggested as a neoadjuvant in the treatment of certain types of cancer.
View Article and Find Full Text PDFBiased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies.
Comput Struct Biotechnol J
December 2024
Centre de Biologie Structurale (CBS), Univ Montpellier, INSERM, CNRS, 34090, Montpellier, France.
G protein-coupled receptors (GPCRs) control critical cell signaling. Their response to extracellular stimuli involves conformational changes to convey signals to intracellular effectors, among which the most important are G proteins and β-arrestins (βArrs). Biased activation of one pathway is a field of intense research in GPCR pharmacology.
View Article and Find Full Text PDFGenetic variations as predictors of dispositional and dyadic empathy-a couple study.
Sci Rep
November 2024
Institute of Physics and Applied Computer Science, Faculty of Applied Physics and Mathematics, Gdańsk University of Technology, Narutowicza 11/12, 80-233, Gdańsk, Poland.
Article Synopsis
- The study explores the genetic basis of empathy by analyzing specific genetic variations linked to oxytocin and vasopressin in heterosexual couples.
- It examines both emotional empathy (like empathic concern) and cognitive empathy (like perspective-taking) using machine learning techniques on a sample of 442 individuals (221 couples).
- Findings show that certain genetic markers significantly influence the emotional and dyadic aspects of empathy, with notable differences between males and females regarding which genes affect their empathic responses.
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