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Nesiritide for pulmonary arterial hypertension with decompensated cor pulmonale. | LitMetric

Nesiritide for pulmonary arterial hypertension with decompensated cor pulmonale.

Prog Cardiovasc Nurs

Pulmonary Hypertension Group, Pulmonary Hypertension Clinic, Cardiovascular Institute, St. Paul University Hospital, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.

Published: February 2006

AI Article Synopsis

Article Abstract

Pulmonary arterial hypertension complicated by decompensated cor pulmonale is a challenging clinical problem with few effective therapeutic options. B-type natriuretic peptide is a pluripotent hormone that promotes diuresis and natriuresis, vasodilates systemic and pulmonary vessels, and reduces circulating levels of endothelin and aldosterone. It may represent a possible therapeutic strategy for decompensated cor pulmonale in the same manner that it is used to treat decompensated left heart failure. The authors report their experience with B-type natriuretic peptide as adjunctive therapy for pulmonary arterial hypertension complicated by decompensated cor pulmonale. A detailed case report is presented followed by the evaluation of a series of 11 cases occurring in eight patients from December 2002 through April 2004.

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Source
http://dx.doi.org/10.1111/j.0889-7204.2005.04696.xDOI Listing

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