Time microscopy for all kinds of data including circadian clock biology.

Biomed Pharmacother

Halberg Chronobiology Center, University of Minnesota, MMC 8609, 420 Delaware Street SE, Minneapolis, MN 55455, USA.

Published: October 2005

Data showing a rhythm to the naked eye prominently, barely or not at all were described as kinds A, B and C, respectively. Here, we document good agreement between estimates of maxima and minima with eyeballing and with the addition of point and interval estimates of parameters in kind A data. We also construct a chart that provides estimates of uncertainties that can be obtained objectively while they are more difficult to quantify subjectively; again there is agreement. Interval as point estimates of rhythm characteristics and parameter comparisons are useful in charting all kinds of data and become indispensable as we proceed from kind A to kind C data. Illustrations included herein from molecular biology apply equally to all aspects of transdisciplinary science.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576450PMC
http://dx.doi.org/10.1016/s0753-3322(05)80005-8DOI Listing

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