Design, synthesis, and anti-Helicobacter pylori activity of erythromycin A (E)-9-oxime ether derivatives.

Bioorg Med Chem Lett

Biochemicals Research Center, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul, Republic of Korea.

Published: February 2006

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Article Abstract

The synthesis and anti-Helicobacter pylori (H. pylori) activity evaluation of a new series of erythromycin A (E)-9-oxime ether derivatives are described. These compounds exhibited comparable in vitro anti-H. pylori activity and improved acid stability compared to the reference compound clarithromycin.

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http://dx.doi.org/10.1016/j.bmcl.2005.10.045DOI Listing

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