The synthesis and biological evaluation of a novel family of M(3) muscarinic antagonists are described. A systematic modification of the substituents to a novel alkyne-quinuclidine scaffold yielded original compounds displaying potent in vitro anticholinergic properties.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2005.09.079 | DOI Listing |
Publication Analysis
Top Keywords
potent anti-muscarinic
4
anti-muscarinic activity
4
activity novel
4
novel series
4
series quinuclidine
4
quinuclidine derivatives
4
derivatives synthesis
4
synthesis biological
4
biological evaluation
4
evaluation novel
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!