Recent studies have indicated that changes in extracellular pH and in membrane voltage affect the gamma-amino-n-butyric acid type A receptor gating mainly by altering desensitization and binding. To test whether the effects of membrane potential and pH are additive, their combined actions were investigated. By analyzing the current responses to rapid gamma-amino-n-butyric acid applications, we found that the current to voltage relationship was close to linear at acid pH but the increasing pH induced an inward rectification. Desensitization was enhanced at depolarizing potentials, but this strongly depended on pH, being weak at acidic and strong at basic pH values. A similar trend was observed for the onset rate of responses to saturating gamma-amino-n-butyric acid concentration. These data provide evidence that the voltage sensitivity of GABAA receptors depends on extracellular pH.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951795 | PMC |
| http://dx.doi.org/10.1097/01.wnr.0000187631.83751.9b | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Plasma Amino Acid Profile in Children with Autism Spectrum Disorder in Southern China: Analysis of 110 Cases.
J Autism Dev Disord
April 2024
Department of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
To retrospectively explore the characteristics of plasma amino acids (PAAs) in children with autism spectrum disorder and their clinical association via case-control study. A total of 110 autistic and 55 healthy children were recruited from 2014 to 2018. The clinical phenotypes included severity of autism, cognition, adaptability, and regression.
View Article and Find Full Text PDFProbiotics and Synbiotics Addition to Bama Mini-Pigs' Diet Improve Carcass Traits and Meat Quality by Altering Plasma Metabolites and Related Gene Expression of Offspring.
Front Vet Sci
July 2022
Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China.
This study evaluated the effects of maternal probiotics and synbiotics addition on several traits and parameters in offspring. A total of 64 Bama mini pigs were randomly allocated into the control (basal diet), antibiotic (50 g/t virginiamycin), probiotics (200 mL/day probiotics), or synbiotics (500 g/t xylo-oligosaccharides and 200 mL/day probiotics) group and fed with experimental diets during pregnancy and lactation. After weaning, two piglets per litter and eight piglets per group were selected and fed with a basal diet.
View Article and Find Full Text PDFGuanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs.
Porcine Health Manag
June 2022
Guanghui Animal Husbandry Co., Ltd., Shaoguan, 512000, China.
Background: As a nutritive feed additive, guanidine acetic acid (GAA) participates in the metabolism of energy and proteins. This study aimed to investigate the effects of GAA on growth performance, organ index, plasma and tissue free amino acid profiles, and related metabolites in finishing pigs. A total of 72 crossbred pigs (body weight 86.
View Article and Find Full Text PDFHepatoprotective effects of gamma-aminobutyric acid-enriched fermented Hovenia dulcis extract on ethanol-induced liver injury in mice.
BMC Complement Med Ther
March 2020
College of Veterinary Medicine, Kyungpook National University, 80, Daehak-ro, Buk-gu, 41566, Daegu, Republic of Korea.
Article Synopsis
- A study was conducted to investigate the effects of fermented Hovenia dulcis extract (FHDE) on liver injury caused by alcohol in mice, using specific bacteria for fermentation.
- The experiment involved feeding C57BL/6 mice a diet containing FHDE and monitoring changes in liver function and biochemistry over 29 days.
- Results showed that FHDE improved weight gain, reduced liver damage markers, and positively influenced gene expression related to alcohol metabolism and antioxidant protection compared to ethanol-treated mice.
Feedback Regulation of N Fixation in Symbiosis Through Amino Acids Profiling in Field and Greenhouse Nodules.
Mol Plant Microbe Interact
March 2020
Université de Lyon, F-69361, Lyon, France, Université Claude Bernard Lyon 1, CNRS, UMR 5557, INRA UMR1418, Ecologie Microbienne, F-69622, Villeurbanne, France.
Symbiosis established between actinorhizal plants and spp., which are nitrogen-fixing actinobacteria, promotes nodule organogenesis, the site of metabolic exchange. The present study aimed to identify amino acid markers involved in - interactions by comparing nodules and associated roots from field and greenhouse samples.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!