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Penicillin Allergy Management in India and Sri Lanka: Current Challenges.
Clin Exp Allergy
January 2025
School of Infection, Inflammation and Immunology, University of Birmingham, Brimingham, UK.
Data regarding Penicillin allergy labels (PALs) from India and Sri Lanka are sparse. Emerging data suggests that the proportion of patients declaring an unverified PAL in secondary care in India and Sri Lanka (1%-4%) is lesser than that reported in High Income Countries (15%-20%). However, even this relatively small percentage translates into a large absolute number, as this part of the world accounts for approximately 25% of the global population.
View Article and Find Full Text PDFSystematic Study of Steroid Drugs' Ability to Cross Biomembranes-The Possible Environmental Impact and Health Risks Associated with Exposure During Pregnancy.
Membranes (Basel)
December 2024
Faculty of Chemistry, University of Lodz, 91-403 Lodz, Poland.
Thirty-seven steroid drugs of different types were investigated in silico for their environmental and pharmacokinetic properties (partition between soil and water, bioaccumulation in aquatic organisms, ability to be absorbed from the gastrointestinal tract and to cross biological barriers-skin, blood-brain barrier and placenta) using on-line tools and novel QSAR models. The same drugs were studied by Molecular Docking in the context of their ability to interact with two enzymes-glutathione S-transferase (GST) and human N-acetyltransferase 2 (NAT2), which are involved in the placenta's protective system against harmful xenobiotics. Steroid drugs are released to the environment from households, hospitals, manufacturing plants and farms (e.
View Article and Find Full Text PDFFirst Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide.
Curr Issues Mol Biol
January 2025
COSLINK, Songpa-gu, Seoul 05819, Republic of Korea.
Polydeoxyribonucleotide (PDRN) has emerged as a potent bioactive compound with proven efficacy in wound healing, tissue regeneration, and anti-inflammatory applications and is predominantly derived from salmonid gonads. However, this study presents a groundbreaking advancement by successfully extracting and characterizing PDRN from microbial sources, specifically , marking the first report to utilize microbial-, biome-, or -derived PDRN (L-PDRN). The findings demonstrate the enhanced biological properties of L-PDRN over traditional salmon-derived PDRN across several assays.
View Article and Find Full Text PDFImmunosuppression and Outcomes in Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck.
Clin Pract
January 2025
Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 800010 Galati, Romania.
Cutaneous squamous scell carcinoma (cSCC) is a frequent non-melanoma skin cancer that originates from keratinocytes with increased prevalence. cSCC can be either in situ, as in Bowen's disease, or extended. Advanced age, accumulated sun exposure, light pigmentation, and prior skin cancer diagnosis are all significant risk factors for cSCC.
View Article and Find Full Text PDFVulvar keratoacanthoma may be a malignant precursor: A case report and literature review.
Gynecol Oncol Rep
February 2025
People's Hospital of China Medical University, Department of Gynecology, People's Hospital of Liaoning Province, Shenyang, China.
Background: Keratoacanthoma is a relatively rare skin tumor, with vulvar keratoacanthoma being even more uncommon. Although the majority of keratoacanthomas exhibit a benign course, a subset of cases may show features of malignant potential, such as marginal invasion and recurrence.
Case: An 82-year-old female presented with a rapidly growing exophytic lesion on the left vulva, measuring 1.
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