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Photocrosslinking and capture for the analysis of carbohydrate-dependent interactions.
Bioorg Med Chem Lett
March 2025
Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA. Electronic address:
Carbohydrates play crucial roles in biological systems, including by mediating cell and protein interactions. The complexity and transient nature of carbohydrate-dependent interactions pose significant challenges for their characterization, as traditional techniques often fail to capture these low-affinity binding events. This review highlights the increasing utility of photocrosslinkers in studying carbohydrate-mediated interactions.
View Article and Find Full Text PDFAntagonistic systemin receptors integrate the activation and attenuation of systemic wound signaling in tomato.
Dev Cell
November 2024
Taishan Academy of Tomato Innovation, Shandong Agricultural University, Tai'an, Shandong 271018, China; Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China; College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an 271018, China. Electronic address:
Pattern recognition receptor (PRR)-mediated perception of damage-associated molecular patterns (DAMPs) triggers the first line of inducible defenses in both plants and animals. Compared with animals, plants are sessile and regularly encounter physical damage by biotic and abiotic factors. A longstanding problem concerns how plants achieve a balance between wound defense response and normal growth, avoiding overcommitment to catastrophic defense.
View Article and Find Full Text PDFGPT4Kinase: High-accuracy prediction of inhibitor-kinase binding affinity utilizing large language model.
Int J Biol Macromol
December 2024
Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Edmond H. Fischer Signal Transduction Laboratory, School of Life Sciences, Jilin University, Qianjin road 2699, Changchun 130012, China. Electronic address:
Article Synopsis
- * GPT-4 demonstrated significant accuracy in predicting binding affinities, achieving 87.31% for RAF and outperforming traditional methods, indicating its potential for more reliable drug discovery processes.
- * Additional testing with other kinases confirmed GPT-4's generalizability, achieving a maximum accuracy of 83.78%, with implications for advancements in biological research and therapeutic development.
BCR ligation selectively inhibits IgE class switch recombination.
bioRxiv
September 2024
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA.
Mechanisms that restrict class switch recombination (CSR) to IgE limit the subsequent production of IgE antibodies and therefore the development of allergic disease. Mice with impaired B cell receptor (BCR) signaling have significantly increased IgE responses, consistent with a role for BCR signaling in IgE regulation. While prior work focused on BCR signaling in IgE-expressing cells to explain these findings, it has been reported that BCR signaling can reduce CSR.
View Article and Find Full Text PDFHemoglobin J-Auckland: a clinically silent low oxygen affinity variant presenting with persistent asymptomatic hypoxemia at high altitude.
Hematology
December 2024
Departments of Internal Medicine, King Khalid University, Abha, Saudi Arabia.
Background: Inherited hemoglobin disorders are common in clinical practice. While qualitative (i.e.
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