A new optimized method for the determination of fibrin clot permeability.

The measurement of fibrin clot permeability is important in the investigation of fibrin clot characteristics. A major disadvantage of the standard measurement techniques is that they are time consuming as they require constant adjustments and monitoring. Presented here is a new method that is easy to perform and does not need continuous adjustments. In addition, the supervision required during the measurement is greatly minimized. When performing the measurement in quadruple, the intra-run coefficient of variation is 11.7%, which is comparable with other reported methods. A (5.1-13.1) x 10(-9) cm reference interval of the permeability coefficient (Ks) among 22 healthy volunteers was established.