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Comparative analysis of the gene family in the whole-genome of five gramineous plants.
Front Plant Sci
December 2024
Department of Plant Sciences, College of Life Sciences, Wuhan University, Wuhan, China.
The Jacalin-related lectins () gene family play a crucial role in regulating plant development and responding to environmental stress. However, a systematic bioinformatics analysis of the gene family in Gramineae plants has been lacking. In this study, we identified 101 JRL proteins from five Gramineae species and classified them into eight distinct clades.
View Article and Find Full Text PDFDeciphering Polymer Interactions in Bioconjugates with Different Architectures by Structural Analysis via Time-resolved Limited Proteolysis Mass Spectrometry.
Angew Chem Int Ed Engl
January 2025
Julius-Maximilians-Universitat Wurzburg, Institute for Pharmacy and Chemistry, Am Hubland, 97074, Würzbrug, GERMANY.
Therapeutic proteins are commonly conjugated with polymers to modulate their pharmacokinetics but often lack a description of the polymer-protein interaction. We deployed limited proteolysis mass spectrometry (LiP-MS) to reveal the interaction of polyethylene glycol (PEG) and PEG alternative polymers with interferon-α2a (IFN). Target conjugates were digested with the specific protease trypsin and a "heavy" 15N-IFN wild type (IFN-WT) for time-resolved quantification of the cleavage dynamics.
View Article and Find Full Text PDFEfficacy and safety of telitacicept in IgA nephropathy: a real-world study.
Ren Fail
December 2025
Division of Nephrology, Department of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Background: IgA nephropathy (IgAN) is the most common primary glomerular disease in the world, and specific therapeutic methods for IgAN are limited. Telitacicept is a humanized fusion protein composed of a transmembrane activator and calcium-modulating cyclophilin ligand interactor receptor and human IgG.
Aim: To evaluate the efficacy and safety of telitacicept in adult patients with IgAN in a real-world study.
Exploring the role of splicing in TP53 variant pathogenicity through predictions and minigene assays.
Hum Genomics
January 2025
Population Health Program, QIMR Berghofer Medical Research Institute, Herston, QLD, 4006, Australia.
Background: TP53 variant classification benefits from the availability of large-scale functional data for missense variants generated using cDNA-based assays. However, absence of comprehensive splicing assay data for TP53 confounds the classification of the subset of predicted missense and synonymous variants that are also predicted to alter splicing. Our study aimed to generate and apply splicing assay data for a prioritised group of 59 TP53 predicted missense or synonymous variants that are also predicted to affect splicing by either SpliceAI or MaxEntScan.
View Article and Find Full Text PDFTriglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation.
Cardiovasc Diabetol
January 2025
Facultat de Medicina i Ciències de la Salut, Unitat de Recerca en Lípids i Arteriosclerosi, Universitat Rovira i Virgili, Reus, Spain.
Backgrounds And Aims: Preclinical studies suggest that a triglyceride (TG)-independent proinflammatory action of apolipoprotein C-III (apoCIII) exists. We aimed to investigate the relationship between circulating apoCIII levels and subclinical inflammation markers across different cohorts with distinctive inflammatory patterns: patients with metabolic disorders (MDs), patients with rheumatoid arthritis (RA), and controls. Specifically, we assessed the associations of apoCIII with acute inflammation biomarkers (e.
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