Extra-medullary myeloid tumours (EMT) have been described after curative treatment for acute myeloid leukaemia (AML) in increasing numbers after allogeneic stem cell transplantation. The sites of manifestations are ubiquitous and the discovery is most frequently guided by symptoms reported by the patient or by findings on clinical examination. This study reports a case of EMT in muscles and the heart 1.5 years after allogeneic transplantation for an AML with t(8;21)(q22;23) who achieved a complete remission by use of an idarubicine-based combination chemotherapy. Pathological and imaging findings are presented and treatment options are discussed.
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http://dx.doi.org/10.1080/10428190500233830 | DOI Listing |
Rev Med Suisse
October 2024
Service d'ORL et de chirurgie cervicofaciale, Centre hospitalier universitaire vaudois, 1011 Lausanne.
Indian J Otolaryngol Head Neck Surg
August 2024
Department of ENT & HNS, AIIMS Raipur, Raipur, India.
Acute Myeloid Leukemia (AML) is the most common leukemia observed in the adult population, accounting for 80% of all leukemia cases. Extramedullary involvement in AML, where leukemic cells are found in organs or tissues outside the blood or bone marrow, is a rare occurrence [1]. The most frequent sites of extramedullary disease include the skin, central nervous system (CNS), and lymph nodes [2, 3].
View Article and Find Full Text PDFLeuk Lymphoma
November 2024
Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Cureus
November 2023
Department of Clinical Hematology, Ibn Sina Hospital, University Mohamed V of Medicine, Rabat, MAR.
Chronic myeloid leukemia (CML) with BCR-ABL1-positive cells is a myeloproliferative neoplasm (MPN) characterized by a chromosomal translocation t(9,22)(q34.1;q11.2), which results in the formation of a Philadelphia (Ph) chromosome containing the BCR-ABL1 fusion gene.
View Article and Find Full Text PDFCureus
July 2023
Internal Medicine, Prince Mohammed Bin Abdulaziz Hospital, National Guard Health Affairs, Madinah, SAU.
Myeloid sarcoma, also known as granulocytic sarcoma or chloroma, is an extra-medullary accumulation of malignant myeloid blast cells, leading to a solid tumor formation. Herein, we report a rare presentation of a case with acute myeloid leukemia (AML), whose disease relapse was clinically evident as acute flaccid paraplegia with a certain sensory level. On thoracic spine magnetic resonance imaging (MRI), an epidural mass compressing the spinal cord at the level of the thoracic spine segment 4 (T4) was found.
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