The main aim of this study was to determine whether ventilatory efficiency during incremental exercise is related to various types of myosin heavy chain (MyHC) content in vastus lateralis in. quadricipitis femoris in young healthy men. The respiratory efficiency was expressed by VE/VCO2 slope, determined during sublactate threshold power outputs of the incremental exercise. A significant negative correlation between V(E)/VCO2 and P(ET)CO2 (amounting to: at rest r = -0.43 p < 0.05; at the LT r = -0.87 p < 0.01; at the VO2 max r = -0.95 p < 0.01) was observed. Moreover, the level of PETCO2 at rest and during exercise was not related to the MyHC content of the vastus lateralis muscle. No relationship between the content of various types of MyHC and respiratory efficiency was found.
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Am J Physiol Heart Circ Physiol
January 2025
Sport Medicine Unit, Careggi University Hospital, Via delle Oblate 4, 50134 Florence, Italy.
The study was designed to investigate the pattern of intraventricular Hemo-Dynamic Forces (HDF) and myocardial performance during exercise in Elite Cyclists (EC). Transthoracic stress echocardiography was performed on nineteen EC and thirteen age-matched sedentary controls (SC) at three incremental exercise intensities based on Heart Rate Reserve (HRR). Left Ventricular (LV) HDF were computed from echocardiography long-axis data sets using a novel technique based on endocardial boundary tracking, both in apex-base and latero-septal directions.
View Article and Find Full Text PDFJ Clin Endocrinol Metab
January 2025
Department of Endocrinology and Nephrology, Nordsjællands Hospital, Hillerød, Denmark.
Introduction: Metabolic responses to glucagon beyond the promotion of endogenous glucose production in type 1 diabetes remains poorly explored. Therefore, we aimed to investigate the metabolic responses to glucagon stimulation in type 1 diabetes and explore whether recent exposure to hypoglycemia would impact glucagon sensitivity.
Research Design And Methods: Twenty-nine participants, 19 with type 1 diabetes and ten healthy controls, underwent a hyperinsulinemic-euglycemic clamp with five-stepwise ascending glucagon injections.
Clin Biomech (Bristol)
January 2025
Faculty of Mechanical Engineering (FEMEC), Federal University of Uberlândia, Uberlândia, MG, Brazil.
Background: Wheelchair users face various health issues, such as cardiac problems, obesity, tissue deformation, and shoulder and wrist injuries. Although the subject of ergometry is known since 1912 and the mechanic of propulsion gesture and wheelchair configuration has been studied over the years, most of the equipment found in the literature are adaptations or lack the tools for standardization of techniques. This paper aims to conduct biomechanical validation of a new wheelchair ergometer (ERGO1) designed for assessing physical fitness and muscle training of the upper limbs of people with disabilities.
View Article and Find Full Text PDFJ Appl Physiol (1985)
January 2025
Physical Activity, Health and Rehabilitation Thematic Research Group, School of Psychology, Sport & Health Sciences, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK.
Type 2 diabetes (T2D) is a metabolic disease associated with cardiovascular dysfunction. The myocardium preferentially uses ketones over free fatty acids as a more energy efficient substrate. The primary aim was to assess the effects of ketone monoester (K) ingestion on cardiac output index ().
View Article and Find Full Text PDFBMC Public Health
January 2025
ZHAW Zurich University of Applied Sciences, School of Health Sciences, Institute of Public Health, Winterthur, Switzerland.
Background: Neck pain is a significant public health issue, especially among office workers, with a prevalence ranging from 42 to 68%. This study aimed to evaluate the cost-utility and cost-benefit of a multi-component intervention targeting neck pain in the general population of office workers in Switzerland. The 12-week multi-component intervention consisted of neck exercises, health promotion information workshops, and workplace ergonomics sessions.
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