We describe a case of intraneural metastasis of a synovial sarcoma, the first published case of a metastasis of a soft-tissue sarcoma to a peripheral nerve.
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Colorectal Cancer: A Brief and Simplified Analysis of a Complex Disease.
Medicina (Kaunas)
December 2024
Department of Medical Genetics, Faculty of Pharmacy, Medical University, 5800 Pleven, Bulgaria.
This study examined factors influencing the onset and progression of colorectal tumors, including patients' epidemiological data, tumor location (right-sided, left-sided, and rectal), histomorphology, perineural or intraneural invasion, lymph node status, immune reactions, mismatch repair (MMR) status, and commonly observed mutations. Our primary goal was to evaluate their predictive and prognostic value and interactions. We analyzed a retrospective cohort of 100 patients with colorectal adenocarcinoma diagnosed between 2020 and 2023, using formalin-fixed paraffin-embedded (FFPE) tumor blocks.
View Article and Find Full Text PDFDifferential expression of TRKB tyrosine kinase in the two histological types of parotid salivary duct carcinoma with cancer aggressiveness.
Oral Oncol
April 2024
Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7, Daigaku-machi, Takatsuki, Osaka 569-8686, Japan.
Parotid salivary duct carcinoma (SDC) is a rare and aggressive parotid gland carcinoma (PGC). SDC has two origins: de novo and ex pleomorphic adenoma (SDC ex PA); however, because of its rarity, the clinical and molecular features of the two types of SDC are not sufficiently understood. Here, we studied the differences in their clinicopathological and molecular features using clinical specimens while comparing them to those of adenoid cystic carcinoma (AdCC), an intermediate-grade PGC.
View Article and Find Full Text PDFSubcategorization of Perineural Invasion and Its Impact on Survival in Patients with Oral Squamous Cell Carcinoma.
Head Neck Pathol
June 2023
Department of Head and Neck Surgical Oncology, Tata Medical Center, Newtown, Kolkata, West Bengal, 700160, India.
Article Synopsis
- This study investigates the prognostic relevance of histologic subcategories of perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) across 207 patients, focusing on factors like nerve size, number of foci, and tumor stage.
- The results indicated that while the size of the involved nerve correlated with cancer stage, other PNI characteristics were not significant for predicting patient outcomes; specifically, larger nerves showed better disease-free survival (DFS) and recurrence-free survival (LRFS).
- The study concludes that histologic subcategorization of PNI lacks prognostic value, but involvement of small nerves signifies poor outcomes, and adding chemotherapy to radiotherapy significantly enhances patient prognosis.*
A novel mechanism for the formation and propagation of neural tumors and lesions through neural highways.
Clin Anat
November 2021
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
By recognizing anatomic and radiologic patterns of rare and often misdiagnosed peripheral nerve tumors/lesions, we have defined mechanisms for the propagation of neural diseases. The novel concept of the nervous system serving as a complex system of "highways" driving the neural and perineural spread of these lesions is described in three examples: Intraneural dissection of joint fluid in intraneural ganglion cysts, perineural spread of cancer cells, and dissemination of unknown concentrations of neurotrophic/inhibitory factors for growth in hamartomas/choristomas of nerve. Further mapping of these pathways to identify the natural history of diseases, the spectrum of disease evolution, the role of genetic mutations, and how these neural pathways interface with the lymphatic, vascular, and cerebrospinal systems may lead to advances in targeted treatments.
View Article and Find Full Text PDFTriple intrathecal chemotherapy for leptomeningeal carcinomatosis in solid tumors: Treatment outcomes, response and their determinants.
Indian J Cancer
November 2021
Department of Medical Oncology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Background: Leptomeningeal carcinomatosis (LC) is the metastatic infiltration of leptomeninges by malignant cells originating from an extrameningeal primary tumor site, either extraneural or intraneural. In the absence of treatment, survival is usually measured in weeks, however with treatment this may be extended to a few months. Our institutional protocol has been to offer intrathecal chemotherapy (ITC) to patients having solid tumors with cerebrospinal fluid (CSF) cytology positive leptomeningeal carcinomatosis.
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