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Reporting of concomitant and rescue topical therapies in atopic dermatitis randomised controlled trials evaluating a systemic treatment: a scoping review.
Br J Dermatol
January 2025
Centre of Evidence Based Dermatology, School of Medicine, Faculty of Medicine & Health Sciences, University of Nottingham, UK.
Background: Randomised controlled trials (RCTs) evaluating new systemic treatments for atopic dermatitis (AD) have increased dramatically over the last decade. These trials often incorporate topical therapies either as permitted concomitant or rescue treatments. Differential use of these topicals post-randomisation introduces potential bias as they may nullify or exaggerate treatment responses.
View Article and Find Full Text PDFVenous thromboembolism in bullous pemphigoid: current evidence and update on systematic review.
Dermatol Reports
January 2025
Dermatology, King Fahad Medical City, Riyadh.
Various studies have shown that individuals with bullous pemphigoid (BP) are more likely to develop venous thromboembolism (VTE). However, it is important to acknowledge that these studies primarily focused on individuals in Western nations, which restricts their generalization to a wider demographic. The present systematic review aims to assess the cumulative risk of VTE in individuals with BP compared to healthy individuals.
View Article and Find Full Text PDFThe Banning of Engineered Stone in Australia: An Evidence-Based and Precautionary Policy.
Int J Soc Determinants Health Health Serv
January 2025
CHU Rennes, Inserm, EHESP, Irset-Institut de Recherche en Santé, Environnement et Travail-UMRS, University of Rennes, Rennes, France.
On December 13, 2023, Australia became the first country to ban engineered stone. This material contains more than 80 percent crystalline silica, agglomerated with resins, metal oxides and other (potentially toxic) substances. Engineered stone has become a mass-market product since the late 1990s and has contributed to a worldwide resurgence of accelerated forms of silicosis and a notable incidence of systemic diseases.
View Article and Find Full Text PDFA critical review on effects of artificial sweeteners on gut microbiota and gastrointestinal health.
J Sci Food Agric
January 2025
Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, Zhuhai, China.
Artificial sweeteners have emerged as popular alternatives to traditional sweeteners, driven by the growing concern over sugar consumption and its associated rise in obesity and metabolic disorders. Despite their widespread use, the safety and health implications of artificial sweeteners remain a topic of debate, with conflicting evidence contributing to uncertainty about their long-term effects. This review synthesizes current scientific evidence regarding the impact of artificial sweeteners on gut microbiota and gastrointestinal health.
View Article and Find Full Text PDFDrug-induced thrombocytopenia severity and toxicity（ditpst）:binary classification of drugs by human thrombocytopenia toxicity.
Expert Opin Drug Saf
January 2025
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Background: Drug-induced thrombocytopenia (DITP) often occurs in patients during clinical treatment. However, clinicians usually fail to distinguish which drugs can be plausible culprits accurately. We aimed to develop a large comprehensive drug benchmark database with DITP toxicity using the recommended method by FDA.
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