[Lethal anaphylactic shock model induced by human mixed serum in guinea pigs].

Objective: To establish an anaphylactic shock model induced by human mixed serum in guinea pigs.

Methods: Eighteen guinea pigs were divided into two groups: sensitized and control, The sensitized group were immunized intracutaneously with human mixed serum and then induced by endocardiac injection after 3 weeks.

Results: Symptoms of anaphylactic shock appeared in the sensitized group. The level of serum IgE were increased in the sensitized group significantly.

Conclusions: An animal model of anaphylactic shock wer established successfully. It provide a tool for both forensic study and anaphylactic shock therapy.