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Association between extracellular DNA levels, markers of inflammation and left ventricular mass index in children with chronic kidney disease.
Sci Rep
January 2025
Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Chronic kidney disease (CKD) is associated with chronic low-grade inflammation, but the primary factors triggering this inflammation remain unclear. Extracellular or cell-free DNA (exDNA) originates from virtually all tissues, being released during cell death, and stimulates the innate immune system. Our study was designed as an observational, cross-sectional cohort study of children with CKD (both before and after kidney transplantation) and controls to analyze associations between exDNA, markers of inflammation, and cardiovascular health.
View Article and Find Full Text PDFFacile fabrication of biocompatible carbon dots from egg white by one-step neutralization heat reaction: a capillary array-based fluorimetric strategy for high-throughput detection of total iron ions in fish blood.
Analyst
January 2025
Huzhou Key Laboratory of Medical and Environmental Application Technologies, School of Life Sciences, Huzhou University, Huzhou 313000, China.
Water-soluble and biocompatible protein carbon dots (P-CDs) were simply prepared from egg white by a rapid one-step neutralization heat reaction. Unexpectedly, the thus-fabricated P-CDs could present excitation-dependent tunable fluorescence that could be quenched specifically by Fe and Fe ions with obvious color changes. A high-throughput fluorimetric platform was thereby developed by coating the P-CDs onto a capillary array for detection of total iron ions in fish blood samples, with a linear concentration range of 0.
View Article and Find Full Text PDFBiological activities of lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites.
Front Pharmacol
January 2025
Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.
This research was designed to investigate the metabolite profiling, phenolics content, and the trypanocidal, nematicidal, antibacterial, antifungal, and free radical scavenging properties of Motyka. The air-dried material was extracted successively with dichloromethane and methanol (UlMeOH). Two phases were obtained from the extract with dichloromethane, one soluble in methanol (UlDCM-s) and the other insoluble (UlDCM-i).
View Article and Find Full Text PDFEffects of dapagliflozin on heart rate variability, cardiac function, and short-term prognosis in early-onset post-myocardial infarction heart failure.
Front Cardiovasc Med
January 2025
Department of Cardiology, Shibei Hospital of Jing'an District, Shanghai, China.
Objective: To investigate the effects of dapagliflozin, in addition to standard therapy, on heart rate variability (HRV), soluble growth stimulation expressed gene 2 protein (sST2), N-terminal pro B-type natriuretic peptide (NT-proBNP), and echocardiographic parameters in patients with early-onset post-myocardial infarction heart failure (HF).
Methods: A total of 98 patients with early-onset post-myocardial infarction HF were enrolled and randomly divided into a control group ( = 48, receiving standard therapy) and an observation group ( = 50, receiving standard therapy plus dapagliflozin 10 mg daily). HRV, cardiac function, and echocardiographic parameters were measured at baseline and after 24 weeks of treatment.
Improving protein hydrolysis and digestibility in biomass through recombinant peptidases (EC 3.4): Opportunities for monogastric animal diets.
Heliyon
January 2025
CIISA - Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Av. da Universidade Técnica, 1300-477, Lisboa, Portugal.
This study investigates the use of recombinant peptidases (EC 3.4) to improve protein hydrolysis and digestibility in , with a focus on addressing the challenge of reduced protein bioavailability for monogastric animals due to resistant protein-pigment formations, such as phycocyanin, and increased digesta viscosity caused by jellification properties. A library of 192 peptidases was generated, from which 142 soluble peptidases were expressed in and subsequently screened for activity against an suspension .
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