A new phenylethanoid glycoside, 2-(3-methoxy-4-hydroxylphenyl) ethyl-O-2",3"-diacetyl-alpha-L-rhamnopyranosyl-(1-->3)-4-O-(E)-feruloyl-beta-D-glucopyranoside, was isolated from the aerial parts of Clerodendrum inerme (L.) Gaertn, together with monomelittoside, melittoside, inerminoside A1, verbascoside, isoverbascoside, campneoside I. Their structures were determined by spectroscopic methods.
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Inflammopharmacology
March 2025
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo, 11562, Egypt.
The present study explores the metabolic profiling and molecular wound-healing mechanisms of Echinacea purpurea (L.) Moench (EP) flowers aqueous (AE) and ethanol (EE) extracts in an excision wound-healing model. Metabolic profiling of the extracts was investigated using UHPLC-ESI-TOF-MS and molecular networking.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
February 2025
Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, 100049 Beijing, China.
Background: Salsolinol (SAL) is a dopamine metabolite and endogenous neurotoxin that exerts neurotoxicity to dopaminergic neurons and is involved in the genesis of Parkinson's disease (PD). However, the machinery underlying SAL-induced neurotoxicity in PD is still being elucidated.
Methods: In the present study, we first used RNA-seq and KEGG analysis to examine differentially expressed genes in SAL-challenged SH-SY5Y cells.
Open Life Sci
February 2025
Department of Chemical Engineering, University of Western Macedonia, 50100, Kozani, Greece.
The Lamiaceae family is one of the widest plant families among Greek flora, consisting of a great variety of species, with the genus being one of its largest representatives, spread to most continents. The genus is also known for its beneficial properties and has been used for years as a traditional remedy for healing various health conditions. , an endemic plant in the Kozani Regional unit, has also been consumed as an infusion by locals and is reported to relieve common cold symptoms, have antimicrobial properties, and contribute to normalizing blood glucose levels.
View Article and Find Full Text PDFChem Asian J
February 2025
Nanyang Technological University, School of chemistry, Chemical Engineering and Biotechnology, SINGAPORE.
Acteoside is a prominent phenylethanoid glycoside (PhG) with diverse pharmacological activities. However, its chemical synthesis has been challenging due to the reliance on extensive protection/deprotection strategies, leading to lengthy routes and low overall yields. Herein, we present a streamlined and efficient synthetic approach that minimizes synthetic complexity while improving overall efficiency.
View Article and Find Full Text PDFPhytomedicine
April 2025
International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China; Neurology and Psychiatry Department, Capio Saint Göran's Hospital, Sankt Göransplan 1, 112 19 Stockholm, Sweden. Electronic address:
Background: Species of the genus Globularia exist in the Mediterranean region spreading upon Macaronesia, northern Europe, and north-eastern Africa. They have valuable biological activities and remarkable phytochemical contents explaining their traditional uses.
Purpose: This study reviews phytochemical, pharmacological progress, clinical trials, and molecular mechanisms of action of Globularia extracts and isolated compounds.
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