Tramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. Analogs of tramadol with deuterium-for-hydrogen replacement at metabolically active sites were prepared and evaluated in vitro and in vivo.
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Influence of bee venom on antinociceptive activity of selected analgesic drugs in hot plate test in mice.
Ann Agric Environ Med
December 2024
Department of Experimental Pharmacology, Institute of Rural Health, Lublin, Poland.
Introduction And Objective: The aim of the study was to investigate the effect of bee venom on the activity of two analgesics: ketoprofen (a non-steroidal anti-inflammatory drug) and tramadol (an opioid drug) in the acute thermal pain model (hot-plate test) in mice.
Material And Methods: Linear regression analysis was used to evaluate the dose-response relationship between logarithms of drug doses and their resultant maximum possible anti-nociceptive effects in the mouse hot-plate test. Doses that increased the anti-nociceptive effect by 20% (ED values) for bee venom, ketoprofen and tramadol, and their combination were calculated from linear equations.
Outside-in hair contamination by blood containing opiates and opioids.
Forensic Sci Int
December 2024
CHRU-Nancy, Service de Pharmacologie Clinique et Toxicologie, Nancy F-54000, France; Université de Lorraine, CNRS, IMoPA, Nancy F-54000, France. Electronic address:
Hair analysis for drugs has become extensively used for forensic investigation in recent years. To best interpret hair drug content in post-mortem conditions, the extent of external contamination by biological fluids, such as blood, must be taken into account to avoid false positive results. The present study evaluated opiates and opioids incorporation into hair from blood containing different concentrations of morphine (MOR), 6-mono-acetyl morphine (6-AM), codeine (COD), dihydrocodeine (DHC), tramadol (TRA), oxycodone (OXY), methadone (MET), 2-ethylidene-1,5-dimethyl-3,3- diphenyl pyrrolidine (EDDP), buprenorphine (BUP) and norbuprenorphine (NBUP).
View Article and Find Full Text PDFReal-world usage pattern, effectiveness and safety of oral tramadol/dexketoprofen trometamol fixed-dose combination in moderate-to-severe acute pain in Asia: a prospective, multicentre, observational study.
BMJ Open
October 2024
Medical Affairs, A Menarini Asia Pacific Holdings Pte Ltd, Singapore.
Objectives: This study aims to determine the usage pattern, effectiveness and safety of oral tramadol 75 mg and dexketoprofen trometamol 25 mg fixed-dose combination (TRAM/DKP FDC) in the short-term treatment of moderate-to-severe acute pain in real-world clinical practice in Asia.
Design: Real-world, prospective, multicentre, observational, phase IV study.
Setting: 13 tertiary-care hospital sites across the Philippines, Thailand, Malaysia and Singapore.
Greener analysis of eleven basic drugs in blood and urine using carbowax 20M based biofluid sampler (BFS) device.
J Chromatogr B Analyt Technol Biomed Life Sci
October 2024
Institute of Forensic Science & Criminology, Panjab University, Chandigarh 160014, India. Electronic address:
Article Synopsis
- * The BFS allows for the collection of biological samples without dilution or pre-treatment, with analytes successfully back-extracted for analysis using gas chromatography-mass spectrometry (GC-MS).
- * The method demonstrated good precision and recovery rates, making it suitable for forensic toxicology applications, while also being evaluated for its environmentally friendly characteristics.
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