AI Article Synopsis
- Pyrethrum and synthetic pyrethroids, like allethrin and permethrin, are commonly used insecticides worldwide.
- A highly sensitive gas-chromatography method has enabled the detection of pyrethrum metabolites in urine, revealing a background level of trans-chrysanthemumdicarboxylic acid (CDCA) indicative of pyrethrum exposure.
- After a day of pyrethrum exposure, CDCA was present in 27 out of 30 test subjects, with the study also showing rapid urinary excretion of CDCA post-ingestion, especially within the first four hours.
Article Abstract
Pyrethrum as well as synthetic pyrethroids like allethrin, resmethrin, phenothrin, tetramethrin, cyfluthrin, cypermethrin, deltamethrin or permethrin are among the insecticides most often used worldwide. With a sensitive and valid gas-chromatographic-high resolution mass spectrometric method, it is possible to detect all pyrethrum and pyrethroid metabolites in one analytical run. Thus, for the first time a background level of trans-chrysanthemumdicarboxylic acid (CDCA) in urine (95th percentile: 0.15 microg/l) as a characteristic, e.g. for a pyrethrum exposure was found. Following a pyrethrum exposure lasting 1 day, CDCA was found in 27 out of 30 subjects with concentrations going up to 54 microg/l urine (mean: 1.1+/-4.4 microg/l). To obtain information about the elimination kinetics of pyrethrum in humans, urinary excretion of CDCA was investigated in three volunteers after oral intake of 0.3mg pyrethrin I. CDCA was detected during the first 36 h after intake with elimination being most rapid during the first 4h (mean elimination half-life: 4.2h).
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| http://dx.doi.org/10.1016/j.toxlet.2005.09.030 | DOI Listing |
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