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Insulin amyloid morphology is encoded in H-bonds and electrostatics interactions ruling protein phase separation.
J Colloid Interface Sci
December 2024
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark; Center for Biopharmaceuticals and Biobarriers in Drug Delivery, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address:
Ion-protein interactions regulate biological processes and are the basis of key strategies of modulating protein phase diagrams and stability in drug development. Here, we report the mechanisms by which H-bonds and electrostatic interactions in ion-protein systems determine phase separation and amyloid formation. Using microscopy, small-angle X-ray scattering, circular dichroism and atomistic molecular dynamics (MD) simulations, we found that anions specifically interacting with insulin induced phase separation by neutralising the protein charge and forming H-bond bridges between insulin molecules.
View Article and Find Full Text PDFInjury-on-a-chip for modelling microvascular trauma-induced coagulation.
Lab Chip
January 2025
Joint Department of Biomedical Engineering, North Carolina State University and University of North Carolina, Chapel Hill, 1840 Entrepreneur Dr., Raleigh, NC, 27695 USA.
Blood coagulation is a highly regulated injury response that features polymerization of fibrin fibers to prevent the passage of blood from a damaged vascular endothelium. A growing body of research seeks to monitor coagulation in microfluidic systems but fails to capture coagulation as a response to disruption of the vascular endothelium. Here we present a device that allows compression injury of a defined segment of a microfluidic vascular endothelium and the assessment of coagulation at the injury site.
View Article and Find Full Text PDFA new form of hazardous microparticulate contamination to the marine environment from ships using heavy fuel oil with exhaust gas scrubbers - Characterization and implications for fate, transport and ecotoxicity.
Sci Total Environ
January 2025
Department of Marine Science, University of Gothenburg, 45178 Fiskebäckskil, Sweden.
Aiming to reduce sulfur oxides emission in the atmosphere, the International Maritime Organization developed regulations on shipping that came into effect in 2020. The new rules incentivized many owners to install scrubber systems on thousands of ships. However, the overall environmental implications of scrubbers is a controversial subject, largely due to the release of acids, metals, and chemicals in the oceans and impact on marine life.
View Article and Find Full Text PDFIn Situ Gelling Silk Fibroin/ECM Hydrogel With Sustained Oxygen Release for Neural Tissue Engineering Applications.
J Biomed Mater Res A
January 2025
Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
In situ gelling, cell-laden hydrogels hold promise for regenerating tissue lesions with irregular shapes located in complex and hard-to-reach anatomical sites. A notable example is the regeneration of neural tissue lost due to cerebral cavitation. However, hypoxia-induced cell necrosis during the vascularization period imposes a significant challenge to the success of this approach.
View Article and Find Full Text PDFNanoparticle and microparticle-based systems for enhanced oral insulin delivery: A systematic review and meta-analysis.
J Nanobiotechnology
December 2024
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Ciudad de Mexico, Mexico.
Diabetes mellitus (DM) prevalence is rising worldwide. Current therapies comprising subcutaneous insulin injections can cause adverse effects such as lipodystrophy, local reactions like redness and swelling, fluid retention, and allergic reactions. Nanoparticle carriers for oral insulin are groundbreaking compared to existing methods because they are non-invasive treatments, showing operational convenience, controlled release profile, and ability to simulate the physiological delivery route into the bloodstream.
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